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Treating Metabolic Acidosis for CKD Progression? Need for Higher Quality Data.

作者信息

Kilduff Stella, Brown Denver D, Melamed Michal L

机构信息

Division of Nephrology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

出版信息

Clin J Am Soc Nephrol. 2025 Jan 1;20(1):147-149. doi: 10.2215/CJN.0000000632. Epub 2024 Nov 20.

DOI:10.2215/CJN.0000000632
PMID:39665575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11875390/
Abstract
摘要

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本文引用的文献

1
KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease.KDIGO 2024慢性肾脏病评估与管理临床实践指南
Kidney Int. 2024 Apr;105(4S):S117-S314. doi: 10.1016/j.kint.2023.10.018.
2
VALOR-CKD: A Multicenter, Randomized, Double-Blind Placebo-Controlled Trial Evaluating Veverimer in Slowing Progression of CKD in Patients with Metabolic Acidosis.VALOR-CKD 研究：一项多中心、随机、双盲、安慰剂对照临床试验，旨在评估维立西呱在代谢性酸中毒患者中延缓 CKD 进展的作用。
J Am Soc Nephrol. 2024 Mar 1;35(3):311-320. doi: 10.1681/ASN.0000000000000292. Epub 2024 Jan 23.
3
Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial.瑞士代谢性酸中毒的肾移植受者中应用碳酸氢钠：一项多中心、随机、单盲、安慰剂对照、3 期临床试验。
Lancet. 2023 Feb 18;401(10376):557-567. doi: 10.1016/S0140-6736(22)02606-X. Epub 2023 Jan 25.
4
Serum Bicarbonate and Graft and Patient Outcomes Among Kidney Transplant Recipients: A Retrospective Cohort Study Evaluating Changes in Serum Bicarbonate Over Time.肾移植受者的血清碳酸氢盐与移植物及患者预后：一项评估血清碳酸氢盐随时间变化的回顾性队列研究
Kidney Med. 2022 Nov 17;5(1):100573. doi: 10.1016/j.xkme.2022.100573. eCollection 2023 Jan.
5
Low Serum Bicarbonate and CKD Progression in Children.血清碳酸氢盐水平低与儿童慢性肾脏病进展。
Clin J Am Soc Nephrol. 2020 Jun 8;15(6):755-765. doi: 10.2215/CJN.07060619. Epub 2020 May 28.
6
Effects of Sodium Bicarbonate in CKD Stages 3 and 4: A Randomized, Placebo-Controlled, Multicenter Clinical Trial.碳酸氢钠对慢性肾脏病 3 期和 4 期的影响：一项随机、安慰剂对照、多中心临床试验。
Am J Kidney Dis. 2020 Feb;75(2):225-234. doi: 10.1053/j.ajkd.2019.07.016. Epub 2019 Nov 5.
7
Treatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: the UBI Study.用碳酸氢钠治疗代谢性酸中毒会延缓慢性肾脏病的进展：UBI 研究。
J Nephrol. 2019 Dec;32(6):989-1001. doi: 10.1007/s40620-019-00656-5. Epub 2019 Oct 9.
8
Veverimer versus placebo in patients with metabolic acidosis associated with chronic kidney disease: a multicentre, randomised, double-blind, controlled, phase 3 trial.维维美尼与安慰剂在代谢性酸中毒合并慢性肾脏病患者中的比较：一项多中心、随机、双盲、对照、3 期临床试验。
Lancet. 2019 Apr 6;393(10179):1417-1427. doi: 10.1016/S0140-6736(18)32562-5. Epub 2019 Mar 8.
9
Treatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen and preserves glomerular filtration rate.用水果和蔬菜或口服碳酸氢盐治疗 3 期慢性肾脏病患者的代谢性酸中毒可减少尿血管紧张素原并维持肾小球滤过率。
Kidney Int. 2014 Nov;86(5):1031-8. doi: 10.1038/ki.2014.83. Epub 2014 Apr 2.
10
Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3.大鼠慢性肾小管间质性疾病的病理生理学。饮食酸负荷、氨与补体成分C3的相互作用。
J Clin Invest. 1985 Aug;76(2):667-75. doi: 10.1172/JCI112020.