Huang Yuheng, Guan Xingmin, Zhang Xinheng, Yoosefian Ghazal, Ho Hao, Huang Li-Ting, Lin Hsin-Yao, Anthony Gregory, Lee Hsu-Lei, Bi Xiaoming, Han Fei, Chan Shing Fai, Vora Keyur P, Sharif Behzad, Singh Dhirendra P, Youssef Khalid, Li Debiao, Han Hui, Christodoulou Anthony G, Dharmakumar Rohan, Yang Hsin-Jung
From the Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Pacific Theatres Bldg, Ste 400, Los Angeles, CA 90048 (Y.H., L.T.H., H.L.L., D.L., H. Han, A.G.C., H.J.Y.); Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, Ind (Y.H., X.G., X.Z., G.Y., G.A., S.F.C., K.P.V., B.S., D.P.S., K.Y., R.D.); Departments of Bioengineering (Y.H., X.Z., A.G.C.) and Statistics (H. Ho), University of California Los Angeles, Los Angeles, Calif; Academia Sinica, Institute of Statistical Science, Nankang, Taipei, Taiwan (H. Ho); Department of Surgery, Division of Neurosurgery, Mackay Memorial Hospital, Taipei, Taiwan (L.T.H.); Department of Medical Imaging, National Cheng Kung University Hospital, Tainan, Taiwan (H.Y.L.); Siemens Medical Solutions USA, Malvern, Pa (X.B., F.H.); and Department of Radiological Sciences, University of California Los Angeles David Geffen School of Medicine, Los Angeles, Calif (A.G.C.).
Radiol Cardiothorac Imaging. 2024 Dec;6(6):e230376. doi: 10.1148/ryct.230376.
Purpose To evaluate the performance of a high-dynamic-range quantitative susceptibility mapping (HDR-QSM) cardiac MRI technique to detect intramyocardial hemorrhage (IMH) and quantify iron content using phantom and canine models. Materials and Methods A free-running whole-heart HDR-QSM technique for IMH assessment was developed and evaluated in calibrated iron phantoms and 14 IMH female canine models. IMH detection and iron content quantification performance of this technique was compared with the conventional iron imaging approaches, R2*(1/T2*) maps, using measurements from ex vivo imaging as the reference standard. Results Phantom studies confirmed HDR-QSM's accurate iron content quantification and artifact mitigation ability by revealing a strong linear relationship between iron concentration and QSM values (, 0.98). In in vivo studies, HDR-QSM showed significantly improved image quality and susceptibility homogeneity in nonaffected myocardium by alleviating motion and off-resonance artifacts (HDR-QSM vs R2*: coefficient of variation, 0.31 ± 0.16 [SD] vs 0.73 ± 0.36 [ < .001]; image quality score [five-point Likert scale:], 3.58 ± 0.75 vs 2.87 ± 0.51 [ < .001]). Comparison between in vivo susceptibility maps and ex vivo measurements showed higher performance of HDR-QSM compared with R2* mapping for IMH detection (area under the receiver operating characteristic curve, 0.96 vs 0.75; < .001) and iron content quantification (, 0.71 vs 0.14). Conclusion In a canine model of IMH, the fast and free-running cardiac QSM technique accurately detected IMH and quantified intramyocardial iron content of the entire heart within 5 minutes without requiring breath holding. High-Dynamic-Range Quantitative Susceptibility Mapping, Myocardial Infarction, Intramyocardial Hemorrhage, MRI ©RSNA, 2024.
目的 评估高动态范围定量磁化率成像（HDR-QSM）心脏磁共振成像（MRI）技术在使用体模和犬类模型检测心肌内出血（IMH）及量化铁含量方面的性能。材料与方法 开发了一种用于IMH评估的自由运行全心脏HDR-QSM技术，并在校准的铁体模和14只患有IMH的雌性犬类模型中进行评估。将该技术的IMH检测和铁含量量化性能与传统铁成像方法R2*（1/T2*）图进行比较，以离体成像测量结果作为参考标准。结果 体模研究通过揭示铁浓度与QSM值之间的强线性关系（，0.98），证实了HDR-QSM准确的铁含量量化和伪影减轻能力。在体内研究中，HDR-QSM通过减轻运动和失谐伪影，在未受影响的心肌中显示出显著改善的图像质量和磁化率均匀性（HDR-QSM与R2比较：变异系数，0.31±0.16[标准差]对0.73±0.36[<.001]；图像质量评分[五点李克特量表：]，3.58±0.75对2.87±0.51[<.001]）。体内磁化率图与离体测量结果的比较显示，与R2映射相比，HDR-QSM在IMH检测（受试者操作特征曲线下面积，0.96对0.75；<.001）和铁含量量化（，0.71对0.14）方面表现更优。结论 在IMH犬类模型中，快速且自由运行的心脏QSM技术能够在5分钟内准确检测IMH并量化整个心脏的心肌内铁含量，无需屏气。高动态范围定量磁化率成像、心肌梗死、心肌内出血、MRI ©RSNA，2024
