Purpose To measure the benefit of single-phase CT, inspiratory-expiratory CT, and clinical data for convolutional neural network (CNN)-based chronic obstructive pulmonary disease (COPD) staging. Materials and Methods This retrospective study included inspiratory and expiratory lung CT images and spirometry measurements acquired between November 2007 and April 2011 from 8893 participants (mean age, 59.6 years ± 9.0 [SD]; 53.3% [4738 of 8893] male) in the COPDGene phase I cohort (ClinicalTrials.gov: NCT00608764). CNNs were trained to predict spirometry measurements (forced expiratory volume in 1 second [FEV], FEV percent predicted, and ratio of FEV to forced vital capacity [FEV/FVC]) using clinical data and either single-phase or multiphase CT. Spirometry predictions were then used to predict Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage. Agreement between CNN-predicted and reference standard spirometry measurements and GOLD stage was assessed using intraclass correlation coefficient (ICC) and compared using bootstrapping. Accuracy for predicting GOLD stage, within-one GOLD stage, and GOLD 0 versus 1-4 was calculated. Results CNN-predicted and reference standard spirometry measurements showed moderate to good agreement (ICC, 0.66-0.79), which improved by inclusion of clinical data (ICC, 0.70-0.85; ≤ .04), except for FEV/FVC in the inspiratory-phase CNN model with clinical data ( = .35) and FEV in the expiratory-phase CNN model with clinical data ( = .33). Single-phase CNN accuracies for GOLD stage, within-one stage, and diagnosis ranged from 59.8% to 84.1% (682-959 of 1140), with moderate to good agreement (ICC, 0.68-0.70). Accuracies of CNN models using inspiratory and expiratory images ranged from 60.0% to 86.3% (684-984 of 1140), with moderate to good agreement (ICC, 0.72). Inclusion of clinical data improved agreement and accuracy for both the single-phase CNNs (ICC, 0.72; ≤ .001; accuracy, 65.2%-85.8% [743-978 of 1140]) and inspiratory-expiratory CNNs (ICC, 0.77-0.78; ≤ .001; accuracy, 67.6%-88.0% [771-1003 of 1140]), except expiratory CNN with clinical data (no change in GOLD stage ICC; = .08). Conclusion CNN-based COPD diagnosis and staging using single-phase CT provides comparable accuracy with inspiratory-expiratory CT when provided clinical data relevant to staging. Convolutional Neural Network, Chronic Obstructive Pulmonary Disease, CT, Severity Staging, Attention Map © RSNA, 2024.