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Amyloid-β is NOT only the most promising target for Alzheimer's disease.

作者信息

Solomon Beka, Voronov-Goldman Milana

机构信息

Department of Molecular Microbiology and Biotechnology, The Shmunis School of Biomedicine and Cancer Research, the George S. Wise Faculty of Life Sciences Tel-Aviv University, Ramat Aviv, Israel.

出版信息

Neural Regen Res. 2026 Feb 1;21(2):681-682. doi: 10.4103/NRR.NRR-D-24-00829. Epub 2024 Dec 7.

DOI:10.4103/NRR.NRR-D-24-00829
PMID:39665791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12220705/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d15/12220705/1a6449f2c313/NRR-21-681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d15/12220705/1a6449f2c313/NRR-21-681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d15/12220705/1a6449f2c313/NRR-21-681-g001.jpg

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本文引用的文献

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Tau-targeting therapies for Alzheimer disease: current status and future directions.针对阿尔茨海默病的靶向 Tau 治疗:现状与未来方向。
Nat Rev Neurol. 2023 Dec;19(12):715-736. doi: 10.1038/s41582-023-00883-2. Epub 2023 Oct 24.
2
Amyloid Precursor Protein and Alzheimer's Disease.淀粉样前体蛋白与阿尔茨海默病。
Int J Mol Sci. 2023 Sep 30;24(19):14794. doi: 10.3390/ijms241914794.
3
Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion.可溶性 APP 片段,sAPPβ,正向调节 tau 分泌。
Neurosci Res. 2023 Aug;193:63-70. doi: 10.1016/j.neures.2023.03.002. Epub 2023 Mar 24.
4
A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ.一个包含大量同基因 APP 和 PSEN1 突变的人 iPSC 神经元的大面板揭示了由 APP β-CTFs 介导的共享内体异常,而不是 Aβ。
Neuron. 2019 Oct 23;104(2):256-270.e5. doi: 10.1016/j.neuron.2019.07.010. Epub 2019 Aug 12.
5
Does Intraneuronal Accumulation of Carboxyl-terminal Fragments of the Amyloid Precursor Protein Trigger Early Neurotoxicity in Alzheimer's Disease?淀粉样前体蛋白羧基末端片段的神经元内积累是否引发阿尔茨海默病早期神经毒性?
Curr Alzheimer Res. 2019;16(5):453-457. doi: 10.2174/1567205016666190325092841.
6
Tau and neurodegenerative disease: the story so far.tau 与神经退行性疾病:迄今为止的研究进展。
Nat Rev Neurol. 2016 Jan;12(1):15-27. doi: 10.1038/nrneurol.2015.225. Epub 2015 Dec 4.
7
Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.淀粉样前体蛋白(APP)代谢产物APP细胞内片段(AICD)、β淀粉样蛋白42(Aβ42)和Tau蛋白的核内作用
J Biol Chem. 2015 Sep 25;290(39):23515-22. doi: 10.1074/jbc.R115.677211. Epub 2015 Aug 21.
8
Inhibition of amyloid precursor protein processing leads to downregulation of apoptotic genes in Alzheimer's disease animal models.淀粉样前体蛋白处理的抑制导致阿尔茨海默病动物模型中凋亡基因的下调。
Neurodegener Dis. 2014;13(2-3):107-9. doi: 10.1159/000353749. Epub 2013 Aug 7.
9
Beneficial effect of antibodies against β- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice.抗 APP β-分泌酶裂解位点抗体对三转基因小鼠阿尔茨海默病样病理的有益作用。
PLoS One. 2012;7(10):e46650. doi: 10.1371/journal.pone.0046650. Epub 2012 Oct 10.
10
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