Dong Juefei, Hou Weibin, Yin Guangming, Wang Jinrong, Wang Long, Liu Jianye, Jiang Xianzhen, Tan Jing
Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.
Int Urol Nephrol. 2025 May;57(5):1615-1623. doi: 10.1007/s11255-024-04324-x. Epub 2024 Dec 12.
To investigate whether the presence of kidney stones increases the risk of developing osteoporosis.
First, we performed an observational study on the basis of data from the National Health and Nutrition Examination Survey (NHANES; 2007-2020). Kidney stone patients were identified on the basis of their affirmative response to the question "Have you ever experienced kidney stones?" (KIQ026). Participants whose T score at the femoral neck was < -2.5 were defined as osteoporosis patients. Multivariable-adjusted logistic regression was used to assess the correlation between the presence of kidney stones and the risk of developing osteoporosis. Second, Mendelian randomization (MR) was applied to further investigate the causal relationship between the presence of kidney stones and the risk of developing osteoporosis. Genetic instruments were obtained from large genome-wide association studies (GWASs) from the UK Biobank and FinnGen Biobank. Inverse-variance weighting (IVW) was the primary analytical method used.
After adjustment for demographic and other covariates, a significant association between the presence of kidney stones and the risk of developing osteoporosis was detected (OR 1.778, CI: 1.345-2.351, P < 0.001). The MR results further revealed that genetically speaking, the presence of kidney stones was causally associated with a greater risk of developing osteoporosis (IVW: OR 1.088, CI: 1.015-1.167, P < 0.05).
The presence of kidney stones is associated with an increased risk of developing osteoporosis. Further prospective cohort studies are needed to validate our results.
探讨肾结石的存在是否会增加患骨质疏松症的风险。
首先，我们基于美国国家健康与营养检查调查（NHANES；2007 - 2020年）的数据进行了一项观察性研究。根据对“您是否曾患过肾结石？”这一问题（KIQ026）的肯定回答来确定肾结石患者。股骨颈T评分＜ -2.5的参与者被定义为骨质疏松症患者。采用多变量调整逻辑回归来评估肾结石的存在与患骨质疏松症风险之间的相关性。其次，应用孟德尔随机化（MR）进一步研究肾结石的存在与患骨质疏松症风险之间的因果关系。遗传工具来自英国生物银行和芬兰生物银行的大型全基因组关联研究（GWAS）。逆方差加权（IVW）是使用的主要分析方法。
在调整人口统计学和其他协变量后，检测到肾结石的存在与患骨质疏松症风险之间存在显著关联（优势比1.778，置信区间：1.345 - 2.351，P＜0.001）。MR结果进一步表明，从基因角度来看，肾结石的存在与患骨质疏松症的更大风险存在因果关联（IVW：优势比1.088，置信区间：1.015 - 1.167，P＜0.05）。
肾结石的存在与患骨质疏松症风险增加相关。需要进一步的前瞻性队列研究来验证我们的结果。
