Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, 130021, China.
College of Software, Jilin University, Changchun, 130012, China.
Endocrine. 2022 Dec;78(3):587-596. doi: 10.1007/s12020-022-03178-6. Epub 2022 Aug 31.
The dietary inflammatory index (DII) is a scoring system to quantify the inflammatory effects of nutrients and foods. Inflammation may affect bone health. The purpose of this study was to explore the relationships of DII with bone mineral density (BMD) and osteoporosis.
This study involved 1023 women and 1080 men (age ≥ 50) in the US National Health and Nutrition Survey (NHANES), 2017-2018. Multivariable linear regression models were used to estimate the associations between DII and BMD. Association between DII and osteoporosis was tested with multivariable logistic regression models.
In women, DII was negatively associated with total hip and femoral neck BMD after adjusting for covariates (P < 0.05). In men, DII was negatively associated with lumbar spine BMD (P < 0.05). DII was positively associated with osteoporosis in women (P < 0.05). The odds ratios (ORs) (95% CI) for osteoporosis associated with DII quartiles 2, 3 and 4 vs. quartile 1 were 2.95 (1.08, 8.09), 5.63 (2.87, 11.04), and 6.14(2.55, 14.78), respectively. No significant association was observed in men.
Higher DII scores were associated with increase osteoporosis risk in women, while no association was found in men. Greater pro-inflammatory diets might be associated with lower BMD in both women and men.
饮食炎症指数（DII）是一种量化营养素和食物炎症效应的评分系统。炎症可能会影响骨骼健康。本研究旨在探讨 DII 与骨密度（BMD）和骨质疏松症的关系。
本研究纳入了美国国家健康和营养调查（NHANES）2017-2018 年的 1023 名女性和 1080 名男性（年龄≥50 岁）。采用多变量线性回归模型来估计 DII 与 BMD 之间的关联。采用多变量逻辑回归模型来检验 DII 与骨质疏松症之间的关联。
在女性中，调整协变量后，DII 与全髋和股骨颈 BMD 呈负相关（P＜0.05）。在男性中，DII 与腰椎 BMD 呈负相关（P＜0.05）。DII 与女性骨质疏松症呈正相关（P＜0.05）。与 DII 四分位 1 相比，四分位 2、3 和 4 与骨质疏松症相关的比值比（OR）（95%CI）分别为 2.95（1.08，8.09）、5.63（2.87，11.04）和 6.14（2.55，14.78）。在男性中未观察到显著相关性。
较高的 DII 评分与女性骨质疏松症风险增加相关，而在男性中未发现相关性。促炎饮食可能与女性和男性的 BMD 降低有关。
