促胰液素和血清素对胃酸分泌的调节。

Regulation of gastric acid secretion by secretin and serotonin.

作者信息

Mate L, Sakamoto T, Greeley G H, Thompson J C

出版信息

Am J Surg. 1985 Jan;149(1):40-5. doi: 10.1016/s0002-9610(85)80007-6.

Abstract

We have tested the interaction between serotonin and secretin in pentagastrin-induced gastric acid secretion in six dogs prepared with Thomas gastric and duodenal cannulas. We further examined the effect of methysergide, a serotonin antagonist, on gastric acid secretion. The intravenous administration of serotonin or secretin alone significantly inhibited pentagastrin-induced gastric acid secretion. The combined administration of serotonin and secretin inhibited gastric acid secretion to a greater magnitude than either secretagogue alone. The administration of methysergide diminished basal concentrations of secretin on gastric acid secretion. Methysergide also enhanced the stimulatory activity of pentagastrin-induced gastric acid secretion. The inhibitory action of intraduodenal acidification of pentagastrin-induced gastric acid secretion was reversed by methysergide.

摘要

我们在六只通过托马斯胃和十二指肠插管制备的犬身上，测试了血清素和促胰液素在五肽胃泌素诱导的胃酸分泌中的相互作用。我们进一步研究了血清素拮抗剂麦角新碱对胃酸分泌的影响。单独静脉注射血清素或促胰液素可显著抑制五肽胃泌素诱导的胃酸分泌。血清素和促胰液素联合给药比单独使用任何一种促分泌素更能抑制胃酸分泌。麦角新碱的给药降低了促胰液素对胃酸分泌的基础浓度。麦角新碱还增强了五肽胃泌素诱导的胃酸分泌的刺激活性。麦角新碱可逆转十二指肠内酸化对五肽胃泌素诱导的胃酸分泌的抑制作用。