Demetriou A A, Kagoma P K, Kaiser S, Seifter E, Niu X T, Levenson S M
Am J Surg. 1985 Jan;149(1):91-4. doi: 10.1016/s0002-9610(85)80015-5.
After a 30 minute period of superior mesenteric artery occlusion in adult rats, there was a significant decrease in peritoneal inflammatory reaction, ileus, peritoneal adhesion formation, and histologically proved bowel wall necrosis in animals given intravenous dimethyl sulfoxide at the end of the ischemic period. In contrast, control rats given normal saline solution intravenously demonstrated severe inflammatory reaction, ileus, hemorrhagic peritoneal fluid, extensive adhesion formation, and areas of bowel wall necrosis. Intravenous glycerol did not have the beneficial effect seen with dimethyl sulfoxide. Neither compound was effective when given intraperitoneally. We conclude that intravenous dimethyl sulfoxide has a significant protective effect in rats with acute intestinal ischemia due to the superior mesenteric artery occlusion in the rat.
成年大鼠肠系膜上动脉闭塞30分钟后，在缺血期结束时静脉注射二甲基亚砜的动物，其腹膜炎症反应、肠梗阻、腹膜粘连形成以及组织学证实的肠壁坏死均显著减轻。相比之下，静脉注射生理盐水的对照大鼠表现出严重的炎症反应、肠梗阻、血性腹膜液、广泛的粘连形成以及肠壁坏死区域。静脉注射甘油未显示出二甲基亚砜所具有的有益效果。两种化合物经腹腔注射均无效。我们得出结论，静脉注射二甲基亚砜对因大鼠肠系膜上动脉闭塞所致急性肠缺血的大鼠具有显著的保护作用。
