重症肌无力中针对内因子的体液免疫和细胞免疫。

Humoral and cellular immunity to intrinsic factor in myasthenia gravis.

作者信息

Zittoun J, Tulliez M, Estournet B, Goulon M

出版信息

Scand J Haematol. 1979 Nov;23(5):442-8. doi: 10.1111/j.1600-0609.1979.tb02747.x.

DOI:10.1111/j.1600-0609.1979.tb02747.x

Abstract

Myasthenia gravis (MG) is an autoimmune disease often associated with other autoimmune disorders. A case history of MG with a coexisting atypical megaloblastic anaemia with vitamin B12 deficiency and anti Intrinsic Factor (IF) antibodies, led to a study of humoral and cellular immunity to IF in 81 MG patients. Within this series, 3 other patients had a disturbed humoral and cellular immunity to IF. These 3 patients presented no other features of pernicious anaemia. The possible origins and significance of the anti IF antibodies in MG patients are discussed.

摘要

重症肌无力（MG）是一种常与其他自身免疫性疾病相关的自身免疫性疾病。一名重症肌无力患者同时患有非典型巨幼细胞贫血伴维生素B12缺乏及抗内因子（IF）抗体，由此对81例重症肌无力患者进行了针对内因子的体液免疫和细胞免疫研究。在该系列研究中，另外3例患者存在针对内因子的体液免疫和细胞免疫紊乱。这3例患者无恶性贫血的其他特征。本文讨论了重症肌无力患者中抗内因子抗体可能的来源及意义。