Wei Yunfei, Zhang Yibo, Zhan Baihe, Wang Yajie, Cheng Jiaqi, Yu Hao, Lv Mengfan, Zhang Yanmin, Zhai Yaxin, Guan Yuan, Feng Haihua
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun 130062, PR China.
College of Animal Science, Jilin University, 5333 Xi'an Road, Changchun, Jilin 130062, PR China.
Phytomedicine. 2025 Jan;136:156317. doi: 10.1016/j.phymed.2024.156317. Epub 2024 Dec 5.
Nonalcoholic fatty liver disease (NAFLD) is a globally prevalent clinical problem of chronic liver disorder whose main pathogenic mechanisms are hepatic lipid accumulation, oxidative stress, and inflammatory reactions. Asiaticoside (Asi) is a compound derived from Centella asiatica, possesses antioxidant, antiphlogistic, antifibrotic, as well as wound healing properties.
The aim of this study was to investigate the effects of Asi on NAFLD and its potential mechanisms.
Two versions of experimental models were constructed using free fatty acids (FFAs)-stimulated HepG2 cells along with high-fat diet (HFD)-incited NAFLD in mice.
The pivotal action of Nrf2 was then explored using Ml-385 or Nrf2 mice.
The results indicated that Asi activated the Nrf2 to alleviate oxidative stress, inhibited the NF-κB to reduce the inflammatory response, and notably decreased lipid droplets and alleviated steatosis.
In conclusion, Asi demonstrates a potential to activate Nrf2 as well as inhibit the NF-κB pathway, there alleviate NAFLD.
非酒精性脂肪性肝病（NAFLD）是一种全球普遍存在的慢性肝脏疾病临床问题，其主要致病机制是肝脏脂质蓄积、氧化应激和炎症反应。积雪草苷（Asi）是一种从积雪草中提取的化合物，具有抗氧化、抗炎、抗纤维化以及促进伤口愈合的特性。
本研究旨在探讨积雪草苷对非酒精性脂肪性肝病的影响及其潜在机制。
使用游离脂肪酸（FFA）刺激的HepG2细胞和高脂饮食（HFD）诱导的小鼠非酒精性脂肪性肝病构建了两种实验模型。
然后使用Ml-385或Nrf2小鼠探讨Nrf2的关键作用。
结果表明，积雪草苷激活Nrf2以减轻氧化应激，抑制NF-κB以减少炎症反应，并显著减少脂滴并减轻脂肪变性。
总之，积雪草苷具有激活Nrf2以及抑制NF-κB途径的潜力，从而减轻非酒精性脂肪性肝病。
