Zeng Zhifeng, Han Wenyuan
National Key Laboratory of Agricultural Microbiology and College of Life Science and Technology, Hubei Hongshan Laboratory, Huazhong Agricultural University, 430070 Wuhan, China.
National Key Laboratory of Agricultural Microbiology and College of Life Science and Technology, Hubei Hongshan Laboratory, Huazhong Agricultural University, 430070 Wuhan, China.
Cell Host Microbe. 2024 Dec 11;32(12):2041-2042. doi: 10.1016/j.chom.2024.11.009.
The sensing of pathogens is the first step for any immune response. A recent paper in Cell reveals that the bacterial Hachiman anti-phage defense system deploys a helicase subunit to sense phage invasion via 3' DNA recognition and subsequent domain rotation to enable nuclease activation.
病原体感知是任何免疫反应的第一步。《细胞》杂志最近发表的一篇论文揭示，细菌的八幡抗噬菌体防御系统通过3' DNA识别和随后的结构域旋转来部署一个解旋酶亚基，以感知噬菌体入侵，从而激活核酸酶。
