Luo QingQing, Zhou LiLi, Luo DaYa, Yu Li
Department of Hematology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi Provincial Key Laboratory of Hematological Diseases (2024SSY06052), Nanchang, Jiangxi, China.
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Crit Rev Oncol Hematol. 2025 Feb;206:104589. doi: 10.1016/j.critrevonc.2024.104589. Epub 2024 Dec 10.
Clonal hematopoiesis (CH) typically refers to the clonal expansion of hematopoietic stem cells (HSCs) due to genetic mutations, serving as the pathogenic basis for various diseases. Clonal hematopoiesis of indeterminate potential (CHIP) is a subtype of CH, emerging as a significant risk factor for myeloid malignancies and cardiovascular diseases, which has attracted increasing attention. However, recent research has unveiled previously overlooked links between CHIP and lymphoma. This paper reviews the relationship between CHIP and lymphoma, focusing on the role and mechanism of TET2 and DNMT3A-mediated CHIP in lymphoma from the perspective of laboratory research and clinical observation. Additionally, we explore the therapeutic implications of targeting CHIP genes and inflammatory pathways in lymphoma. Our findings underscore the multifaceted influence of CHIP on lymphoma development and provide a promising avenue for therapeutic interventions in CHIP mediated lymphoma.
克隆性造血（CH）通常是指由于基因突变导致造血干细胞（HSCs）的克隆性扩增，是各种疾病的致病基础。意义未明的克隆性造血（CHIP）是CH的一种亚型，已成为髓系恶性肿瘤和心血管疾病的重要危险因素，受到越来越多的关注。然而，最近的研究揭示了CHIP与淋巴瘤之间以前被忽视的联系。本文综述了CHIP与淋巴瘤之间的关系，从实验室研究和临床观察的角度，重点探讨了TET2和DNMT3A介导的CHIP在淋巴瘤中的作用和机制。此外，我们还探讨了针对淋巴瘤中CHIP基因和炎症途径的治疗意义。我们的研究结果强调了CHIP对淋巴瘤发展的多方面影响，并为CHIP介导的淋巴瘤治疗干预提供了一条有前景的途径。
