Dadgar Iman, Norström Thor, Ramstedt Mats
Swedish Institute for Social Research, Stockholm University, Stockholm, Sweden.
Center for Educational Leadership and Excellence, Stockholm School of Economics, Stockholm, Sweden.
Drug Alcohol Rev. 2025 Feb;44(2):411-423. doi: 10.1111/dar.13984. Epub 2024 Dec 12.
A growing body of evidence has established alcohol consumption as a causative factor in an increasing array of cancer types, thereby positioning it as a leading global risk factor for cancer. Surprisingly, there is a scarcity of studies examining the extent to which shifts in population drinking affect cancer mortality, despite the substantial public health implications. This paper aims to: (i) estimate the impact of changes in per capita alcohol consumption on both overall cancer mortality rates and specific types of alcohol-related cancer; and (ii) assess whether the association between cancer and population alcohol consumption is influenced by a country's drinking patterns.
We used time-series data for 19 high-income countries spanning the period 1960-2018. Cigarette sales and GDP per capita were included as control variables. The data were analysed using first-difference modelling. The World Health Organization drinking patterns score was used to evaluate a country's drinking pattern.
Our findings revealed that a 1 L per capita increase in alcohol consumption was associated with a 0.9% rise in total cancer mortality among women and a 1.1% increase among men. Notably, among men, the association was more pronounced for cancers with strong evidence of alcohol's effect and for prostate cancer. For women, the alcohol effect was statistically significant for breast cancer. Generally, the estimated alcohol effects were elevated in the country group with more harmful drinking patterns.
Our results indicate that lowering per capita alcohol consumption is likely to reduce cancer mortality.
越来越多的证据表明,饮酒是导致越来越多癌症类型的一个致病因素,因此它被定位为全球癌症的主要风险因素。令人惊讶的是,尽管对公共卫生有重大影响,但很少有研究考察人群饮酒变化对癌症死亡率的影响程度。本文旨在:(i)估计人均酒精消费量变化对总体癌症死亡率和特定类型酒精相关癌症的影响;(ii)评估癌症与人群酒精消费之间的关联是否受一个国家饮酒模式的影响。
我们使用了19个高收入国家1960 - 2018年期间的时间序列数据。将香烟销量和人均国内生产总值作为控制变量。数据采用一阶差分建模进行分析。世界卫生组织饮酒模式评分用于评估一个国家的饮酒模式。
我们的研究结果显示,人均酒精消费量每增加1升,女性的总癌症死亡率上升0.9%,男性上升1.1%。值得注意的是,在男性中,对于有充分证据表明酒精有影响的癌症以及前列腺癌,这种关联更为明显。对于女性,酒精对乳腺癌的影响在统计学上具有显著性。一般来说,在饮酒模式更有害的国家组中,估计的酒精影响更大。
我们的结果表明,降低人均酒精消费量可能会降低癌症死亡率。