2024年9月，日本一所小学爆发了甲型H1N1流感病毒（pdm09）抗原变异株疫情，这些变异株对奥司他韦和帕拉米韦表现出交叉耐药性。
An outbreak of influenza A(H1N1)pdm09 antigenic variants exhibiting cross-resistance to oseltamivir and peramivir in an elementary school in Japan, September 2024.
作者信息
Takashita Emi, Shimizu Kohei, Usuku Shuzo, Senda Ryuichi, Okubo Ichiro, Morita Hiroko, Nagata Shiho, Fujisaki Seiichiro, Miura Hideka, Kishida Noriko, Nakamura Kazuya, Shirakura Masayuki, Ichikawa Masataka, Matsuzaki Yoko, Watanabe Shinji, Takahashi Yoshimasa, Hasegawa Hideki
机构信息
Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Tokyo, Japan.
These authors contributed equally to this work and share first authorship.
出版信息
Euro Surveill. 2024 Dec;29(50). doi: 10.2807/1560-7917.ES.2024.29.50.2400786.
An outbreak of influenza A(H1N1)pdm09 viruses exhibiting cross-resistance to oseltamivir and peramivir occurred in Yokohama, Japan, in September 2024. Among 24 students in a class, 11 were diagnosed with influenza or influenza-like illness, and viruses harbouring the NA H275Y and HA Q210H substitutions were isolated from four. Deep sequencing analysis confirmed the clonal spread of these mutants. Antigenic analysis revealed differences from the vaccine strain. Continued monitoring is crucial to assess the potential for further spread of these mutant viruses.
2024年9月，日本横滨发生了一起甲型H1N1pdm09流感病毒疫情，这些病毒对奥司他韦和帕拉米韦表现出交叉耐药性。在一个班级的24名学生中，有11人被诊断患有流感或流感样疾病，从4人身上分离出了携带NA H275Y和HA Q210H置换的病毒。深度测序分析证实了这些突变体的克隆传播。抗原分析显示与疫苗株存在差异。持续监测对于评估这些突变病毒进一步传播的可能性至关重要。
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