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用于估计同级医院对住院患者结局的直接和间接影响的贝叶斯分层网络自相关模型。

Bayesian hierarchical network autocorrelation models for estimating direct and indirect effects of peer hospitals on outcomes of hospitalized patients.

作者信息

Chen Guanqing, O'Malley A James

机构信息

Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA.

Department of Biomedical Data Science , Geisel School of Medicine at Dartmouth, Lebanon, NH 03756 USA.

出版信息

Appl Netw Sci. 2024;9(1):24. doi: 10.1007/s41109-024-00627-1. Epub 2024 Jun 14.

Abstract

UNLABELLED

When an hypothesized peer effect (also termed social influence or contagion) is believed to act between units (e.g., hospitals) above the level at which data is observed (e.g., patients), a network autocorrelation model may be embedded within a hierarchical data structure thereby formulating the peer effect as a dependency between latent variables. In such a situation, a patient's own hospital can be thought of as a mediator between the effects of peer hospitals and their outcome. However, as in mediation analyses, there may be interest in allowing the effects of peer units to directly impact patients of other units. To accommodate these possibilities, we develop two hierarchical network autocorrelation models that allow for direct and indirect peer effects between hospitals when modeling individual outcomes of the patients cared for at the hospitals. A Bayesian approach is used for model estimation while a simulation study assesses the performance of the models and sensitivity of results to different prior distributions. We construct a United States New England region patient-sharing hospital network and apply newly developed Bayesian hierarchical models to study the diffusion of robotic surgery and hospital peer effects in patient outcomes using a cohort of United States Medicare beneficiaries in 2016 and 2017. The comparative fit of models to the data is assessed using Deviance information criteria tailored to hierarchical models that include peer effects as latent variables.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s41109-024-00627-1.

摘要

未标注

当假定的同伴效应(也称为社会影响或传染)被认为在高于观测数据的单位(如医院)层面上的单位之间起作用时(如患者),网络自相关模型可嵌入分层数据结构中,从而将同伴效应表述为潜在变量之间的依赖性。在这种情况下,患者所在的医院可被视为同伴医院的效应与其结果之间的中介。然而,如同在中介分析中一样,可能会有兴趣允许同伴单位的效应直接影响其他单位的患者。为了适应这些可能性,我们开发了两个分层网络自相关模型,在对医院所护理患者的个体结果进行建模时,允许医院之间存在直接和间接的同伴效应。采用贝叶斯方法进行模型估计,同时通过模拟研究评估模型的性能以及结果对不同先验分布的敏感性。我们构建了美国新英格兰地区患者共享医院网络,并应用新开发的贝叶斯分层模型,使用2016年和2017年美国医疗保险受益人群体来研究机器人手术的扩散以及医院同伴效应在患者结果中的作用。使用针对包含同伴效应作为潜在变量的分层模型量身定制的偏差信息准则来评估模型与数据的比较拟合度。

补充信息

在线版本包含可在10.1007/s41109-024-00627-1获取的补充材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7da5/11636997/bf53b5ee875a/41109_2024_627_Fig1_HTML.jpg

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