Honn K V, Onoda J M, Pampalona K, Battaglia M, Neagos G, Taylor J D, Diglio C A, Sloane B F
Biochem Pharmacol. 1985 Jan 15;34(2):235-41. doi: 10.1016/0006-2952(85)90130-3.
Three calcium channel blockers of the dihydropyridine class were tested in vitro for their effects on tumor cell-platelet-endothelial cell interactions and in vivo for antimetastatic properties. Felodipine, nimodipine and nifedipine inhibited tumor cell-induced platelet aggregation in vitro in a dose-dependent manner. These compounds also inhibited platelet-enhanced tumor cell adhesion to endothelial cells in vitro. Lung colony formation ("experimental" metastasis) and spontaneous pulmonary metastasis were inhibited by felodipine, nimodipine and nifedipine. From the present studies on three calcium channel blockers of the dihydropyridine class we hypothesize that calcium channel blockers may represent a new generic class of antimetastatic agents.
对三种二氢吡啶类钙通道阻滞剂进行了体外实验，观察它们对肿瘤细胞-血小板-内皮细胞相互作用的影响，并进行了体内抗转移特性研究。非洛地平、尼莫地平和硝苯地平在体外以剂量依赖方式抑制肿瘤细胞诱导的血小板聚集。这些化合物在体外也抑制血小板增强的肿瘤细胞与内皮细胞的黏附。非洛地平、尼莫地平和硝苯地平抑制了肺集落形成（“实验性”转移）和自发性肺转移。基于目前对三种二氢吡啶类钙通道阻滞剂的研究，我们推测钙通道阻滞剂可能代表一类新型的抗转移药物。
