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Aging-related inflammatory and metabolic disorder in the novel mutation of in CSF1R-microglial encephalopathy.

作者信息

Wang Xiaohong, Wang Yanli, Jiang Tianlin, Jiang Jiwei, Wang Linlin, Yang Shiyi, Sun Mengfan, Zhang Yuan, Jia Ziyan, Li Wenyi, Ren Qiwei, Zhang Cuicui, Liu Jianjian, Zhu Yinwei, Zhao Min, Jiang Shirui, Zhang Huiying, Chen Jinglong, Xu Jun

机构信息

Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225000, China.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

出版信息

Genes Dis. 2024 Apr 5;12(2):101289. doi: 10.1016/j.gendis.2024.101289. eCollection 2025 Mar.

DOI:10.1016/j.gendis.2024.101289
PMID:39669550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11635720/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/46b653878906/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/e2d91067f6ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/44c6fb76869b/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/695437df65e0/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/d280704cc90f/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/cbb611257f13/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/46b653878906/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/e2d91067f6ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/44c6fb76869b/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/695437df65e0/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/d280704cc90f/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/cbb611257f13/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc51/11635720/46b653878906/figs5.jpg

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引用本文的文献

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Front Genet. 2025 Aug 15;16:1593964. doi: 10.3389/fgene.2025.1593964. eCollection 2025.

本文引用的文献

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J Neuroinflammation. 2023 May 31;20(1):134. doi: 10.1186/s12974-023-02774-1.
2
Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia: Review of Clinical Manifestations as Foundations for Therapeutic Development.成人起病的伴有轴突球状体和色素性神经胶质细胞的白质脑病：基于治疗发展的临床表现综述
Front Neurol. 2022 Feb 3;12:788168. doi: 10.3389/fneur.2021.788168. eCollection 2021.
3
Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo.
集落刺激因子 1 受体（CSF1R）调节小胶质细胞密度和分布，但不调节小胶质细胞分化体内。
Cell Rep. 2018 Jul 31;24(5):1203-1217.e6. doi: 10.1016/j.celrep.2018.06.113.
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Diagnostic criteria for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia due to CSF1R mutation.CSF1R 突变相关性成人发病脑白质病伴轴索性包涵体和色素性星形胶质细胞病的诊断标准。
Eur J Neurol. 2018 Jan;25(1):142-147. doi: 10.1111/ene.13464. Epub 2017 Oct 19.