Grosu Horiana, Cabrera Manuel, Lizarraga Madrigal Daniella, Sainz Zuniga Paula Valeria, Ost David
Pulmonary Medicine, MD Anderson Cancer Center, Houston, USA.
Internal Medicine, Instituto Tecnologico y de Estudios Superiores de Monterrey, Monterrey, MEX.
Cureus. 2024 Nov 12;16(11):e73544. doi: 10.7759/cureus.73544. eCollection 2024 Nov.
Pleural recurrence has been reported after thoracic surgery and radiation treatment, and reports show that the surgery as the first treatment may be associated with an increased incidence of pleural recurrence. The main objective of this study was to compare the incidence of ipsilateral pleural recurrence in patients with non-small cell lung cancer (NSCLC) who underwent surgical resection or curative-intent radiotherapy.
We performed a retrospective cohort study of patients aged 18 or older with stage I NSCLC who underwent surgical resection or curative-intent radiotherapy at our institution. The primary outcome of interest was an incidence of ipsilateral pleural recurrence at the time of first cancer recurrence. Secondary outcomes were the time of any first recurrence type of biopsy approach and the incidence of pleural recurrence.
Our cohort included 512 patients for whom complete data were available. Of these, 50 (9.7%) patients experienced recurrence and 51 died during the five-year follow-up since their first treatment. There was no difference in the incidence of ipsilateral pleural recurrence (P=0.348), the incidence of any recurrence (P=0.069), or time to first recurrence (P=0.088) between the curative intent surgery and radiotherapy groups. Biopsy type was not associated with recurrence.
There was no difference in the incidence of ipsilateral pleural recurrence between the curative intent surgery and radiotherapy groups.
胸外科手术和放射治疗后已报道有胸膜复发情况，且报告显示手术作为首要治疗方式可能与胸膜复发发生率增加有关。本研究的主要目的是比较接受手术切除或根治性放疗的非小细胞肺癌（NSCLC）患者同侧胸膜复发的发生率。
我们对在本机构接受手术切除或根治性放疗的18岁及以上I期NSCLC患者进行了一项回顾性队列研究。感兴趣的主要结局是首次癌症复发时同侧胸膜复发的发生率。次要结局是任何首次复发类型的活检方法的时间以及胸膜复发的发生率。
我们的队列包括512例可获得完整数据的患者。其中，50例（9.7%）患者在首次治疗后的五年随访期间出现复发，51例死亡。根治性手术组和放疗组在同侧胸膜复发发生率（P = 0.348）、任何复发的发生率（P = 0.069）或首次复发时间（P = 0.088）方面均无差异。活检类型与复发无关。
根治性手术组和放疗组在同侧胸膜复发发生率方面无差异。
