Harahap Agnes S, Charles Stefanny, Ham Maria F
Anatomical Pathology Department, Faculty of Medicine, Dr. Cipto Mangunkusumo/Universitas Indonesia, Jakarta, IDN.
Human Cancer Research Center, Indonesian Medical Education and Research Institute, Jakarta, IDN.
Cureus. 2024 Nov 11;16(11):e73482. doi: 10.7759/cureus.73482. eCollection 2024 Nov.
Background Classical Hodgkin lymphoma (cHL) is a lymphoid malignancy originating from germinal center B cells, predominantly affecting young adults. The clinical profile, histologic subtypes, and immunohistochemical (IHC) patterns play crucial roles in diagnosing cHL and predicting prognosis. This study examines the prevalence, clinicopathological features, and IHC patterns of cHL at Dr. Cipto Mangunkusumo Hospital in Jakarta, Indonesia, based on large-scale data collected over a decade. Methods This retrospective analysis included 739 confirmed cases of cHL from 2014 to 2023, identified using hematoxylin and eosin staining and an IHC panel. Data on patient demographics, tumor locations, and stages were collected from medical records. The IHC markers utilized were CD20, CD3, CD30, CD15, PAX5, MUM1, Ki67, and CD45. Chi-square and Fisher exact tests were employed to analyze the distribution of subtypes across different age groups and stages. Result The most affected age group was 20-29 years, comprising 239 cases (32.34%), with a male predominance of 396 cases (53.59%). The majority of tumors were located in nodal areas, accounting for 532 cases (84.31%), while 99 cases (15.69%) were found in extranodal sites, predominantly in the mediastinum. The nodular sclerosis (NS) subtype was the most frequent, accounting for 461 cases (62.38%), followed by mixed cellularity, lymphocyte-depleted, and lymphocyte-rich classical Hodgkin lymphoma. Most cases were diagnosed at early stages (I-III), with NS significantly associated with early-stage diagnosis (OR 3.06, 95% confidence interval (CI) 1.30-7.22). Conclusion The occurrence of HL in terms of prevalence, age, gender, and stage in our study is similar to other Asian countries. Notable correlations were observed between HL subtypes with age and stage.
背景 经典型霍奇金淋巴瘤（cHL）是一种起源于生发中心B细胞的淋巴恶性肿瘤，主要影响年轻成年人。临床特征、组织学亚型和免疫组化（IHC）模式在cHL的诊断和预后预测中起着关键作用。本研究基于十年来收集的大规模数据，考察了印度尼西亚雅加达西托·曼古库苏莫医院cHL的患病率、临床病理特征和IHC模式。方法 这项回顾性分析纳入了2014年至2023年确诊的739例cHL病例，通过苏木精和伊红染色以及免疫组化检测板进行鉴定。从病历中收集患者人口统计学、肿瘤位置和分期的数据。所使用的免疫组化标志物为CD20、CD3、CD30、CD15、PAX5、MUM1、Ki67和CD45。采用卡方检验和Fisher精确检验分析不同年龄组和分期的亚型分布。结果 受影响最严重的年龄组为20 - 29岁，共239例（32.34%），男性占优势，为396例（53.59%）。大多数肿瘤位于淋巴结区域，占532例（84.31%），而99例（15.69%）位于结外部位，主要在纵隔。结节硬化（NS）亚型最为常见，占461例（62.38%），其次是混合细胞型、淋巴细胞消减型和富于淋巴细胞型经典型霍奇金淋巴瘤。大多数病例在早期（I - III期）被诊断，NS与早期诊断显著相关（比值比3.06，95%置信区间（CI）1.30 - 7.22）。结论 我们研究中HL在患病率、年龄、性别和分期方面的发生情况与其他亚洲国家相似。观察到HL亚型与年龄和分期之间存在显著相关性。
