Jot Kiran, Sharath Reddipalli, Bhutia Ongkila, Surya Varun
Department of Oral Pathology and Microbiology, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
J Oral Maxillofac Pathol. 2024 Jul-Sep;28(3):488-492. doi: 10.4103/jomfp.jomfp_72_24. Epub 2024 Oct 15.
This case report presents a rare benign salivary gland tumour called sialadenoma papilliferum. It comprises 3 to 5% of head and neck tumours and about 1% of all minor salivary gland tumours. The focus is on discussing the BRAFV600E mutation analysis and exploring its clinical implications, along with delving into the histopathological differentials. We documented a 73-year-old male, who had a white patch in the left retromolar trigone region for 6 months. The tumour was excised with a clinical diagnosis of verrucous lesion. Microscopic examination revealed exophytic hyperplastic parakeratotic stratified squamous epithelium and endophytic ductal papillary proliferation. The BRAFV600E mutation was present in the patient. Subsequent regular follow-ups were conducted, revealing no recurrence of the condition. This case underscores the pivotal role of BRAFV600E analysis as an invaluable diagnostic tool when confronted with the intricacies of intraoral salivary gland neoplasms.
本病例报告介绍了一种罕见的良性唾液腺肿瘤，称为乳头状唾液腺瘤。它占头颈部肿瘤的3%至5%，约占所有小唾液腺肿瘤的1%。重点是讨论BRAFV600E突变分析并探讨其临床意义，同时深入研究组织病理学鉴别诊断。我们记录了一名73岁男性，其左磨牙后三角区有白色斑块6个月。肿瘤被切除，临床诊断为疣状病变。显微镜检查显示外生性增生性不全角化复层鳞状上皮和内生性导管乳头状增生。患者存在BRAFV600E突变。随后进行了定期随访，未发现病情复发。本病例强调了BRAFV600E分析在面对口腔内唾液腺肿瘤的复杂性时作为一种宝贵诊断工具的关键作用。
