Kommalapati Vatsalya, Rajkumar N Govind, Karri Roja Lakshmi, Ashok Sahana, Kumar A Sudarshan, Srilakshmi D
Department of Oral and Maxillofacial Pathology, SIBAR Institute of Dental Sciences Takkellapadu, Guntur, Andhra Pradesh, India.
Department of Oral and Maxillofacial Pathology, GSL Dental College and Hospital, Rajamahendravaram, Andhra Pradesh, India.
J Oral Maxillofac Pathol. 2024 Jul-Sep;28(3):369-373. doi: 10.4103/jomfp.jomfp_301_23. Epub 2024 Oct 15.
The study aims to investigate the antifungal efficacy of albedo extract of Punica grantum on candida albicans by evaluating the inhibitory capacity of alcoholic albedo extracts by disc diffusion method and by comparing the antifungal efficacy of alcoholic extract of albedo with clotrimazole and ethanol.
Using a conventional disc diffusion method, the effectiveness of Punica Granatum albedo extract against Candida albicans was assessed and evaluated depending on the presence or absence of inhibition zones, as well as the average diameter of inhibition zones. Albedo extract of Punica granatum serial dilutions were prepared ranging from 1%, 5%, 10%, 15%, 20% and 25% and its antifungal efficacy was tested against Candida albicans in comparison with clotrimazole and ethanol.
When compared to clotrimazole, the albedo extract of punica granatum showed significant anticandidal activity. The mean zone of inhibition of extract was recorded at 27.6 mm whereas clotrimazole was 21.6 mm and no zone of inhibition was recorded for ethanol. Statistically significant p value 0.015 was recorded within the different dilutions of albedo extract of Punica grantum which is less than 0.05.
The present investigation found that Punica Granatum albedo extract had greater potent antifungal activity when compared to clotrimazole and ethanol.
本研究旨在通过纸片扩散法评估石榴皮提取物的乙醇提取物的抑菌能力，并将其与克霉唑和乙醇的抗真菌效果进行比较，以研究石榴皮提取物对白色念珠菌的抗真菌效果。
采用传统的纸片扩散法，根据抑菌圈的有无以及抑菌圈的平均直径，评估和评价石榴皮提取物对白色念珠菌的有效性。制备了浓度范围为1%、5%、10%、15%、20%和25%的石榴皮提取物系列稀释液，并将其与克霉唑和乙醇相比，测试其对白色念珠菌的抗真菌效果。
与克霉唑相比，石榴皮提取物显示出显著的抗念珠菌活性。提取物的平均抑菌圈为27.6毫米，而克霉唑为21.6毫米，乙醇未观察到抑菌圈。石榴皮提取物不同稀释度之间的p值具有统计学意义，为0.015，小于0.05。
本研究发现，与克霉唑和乙醇相比，石榴皮提取物具有更强的抗真菌活性。
