Jayan Lekshmy, Priyadharsini N, Ramya R, Rajkumar K
Department of Oral and Maxillofacial Pathology and Microbiology, SRM Dental College, Chennai, Tamil Nadu, India.
J Oral Maxillofac Pathol. 2020 Sep-Dec;24(3):517-522. doi: 10.4103/jomfp.JOMFP_355_19. Epub 2021 Jan 9.
Antifungal resistance shown by different species of has affected the management of candidiasis drastically. This has led to the need for newer safer therapeutic alternatives for their management. Phytochemical agents have been long known to possess numerous medicinal activities.
The aim of this study was to evaluate the efficacy and resistance of fluconazole and to compare the antifungal effects of Coriandrum sativum, Mentha piperita and Punica granatum in .
The organism was inoculated into a specific medium, and extracts are added at serial dilutions and incubated to evaluate the zone of inhibition.
All the three extracts showed statistically significant and superior antifungal activity to fluconazole in fluconazole-resistant .
Although the extracts showed superior antifungal activity in resistant strains, further studies are needed to evaluate these extracts in patients to see if their efficacy is impeded by any systemic or local factors in the body.
不同念珠菌属表现出的抗真菌耐药性极大地影响了念珠菌病的治疗。这导致需要更新的、更安全的治疗替代方案来进行管理。长期以来，人们已知植物化学制剂具有多种药用活性。
本研究的目的是评估氟康唑的疗效和耐药性，并比较胡荽、薄荷和石榴在念珠菌中的抗真菌作用。
将该生物体接种到特定培养基中，以系列稀释度添加提取物并进行培养，以评估抑菌圈。
在耐氟康唑的念珠菌中，所有三种提取物均显示出具有统计学意义的、优于氟康唑的抗真菌活性。
尽管这些提取物在耐药念珠菌菌株中显示出优异的抗真菌活性，但仍需要进一步研究以在患者中评估这些提取物，以确定其疗效是否会受到体内任何全身或局部因素的影响。
