Selim Farah, Baig Mirza, Magoury Mohamed, Ahmed Waqar, Mahmoud Mansour A
Department of Pharmacy Practice, Dubai Pharmacy College for Girls, Dubai, UAE.
Director of Pharmacy Operations, The Life Corner, Pure Health, Abu Dhabi, UAE.
Arch Acad Emerg Med. 2024 Nov 11;13(1):e16. doi: 10.22037/aaem.v13i1.2470. eCollection 2025.
Drug therapy-related problems (DTRP) can lead to avoidable negative health consequences, particularly during hospital admissions. This study aimed to assess the frequency, causes, and associated factors of DTRPs, which are detected by clinical pharmacists' interventions.
This is a prospective cross-sectional study of patients admitted to the medical wards of Fakeeh University Hospital, UAE, over a three-month period from September 2022 to December 2022. The data of patients who were assessed by clinical pharmacists regarding the pretense and causes of DTRPs were collected and analyzed using SPSS version 27.0.
310 patients with the mean age of 33.43 ± 19.98 years were studied (53.9% male). The highest percentage of patients were Asian (31.0%) and Arabs (30.6%). 79 (25.4%) cases had no DTRPs, while 231 (74.6) had DTRPs. The surgical ward had the highest frequency of DTRPs (41.0%). Improper drug selection with 79 cases, drug use without indication with 73 cases, and sub-therapeutic dosage with 26 cases were among the most common causes of DTRPs. Alcohol intake (p= 0.03), food allergy (p = 0.02), age group 31-40 years (p = 0.04), presence of co-morbidities (p = 0.01), family history of diseases (p = 0.02), and admission to the intensive care unit (ICU) (p = 0.01) were amongst the significantly associated factors of DTRPs. The acceptance status for clinical pharmacists' interventions were complete in 90.0% of cases, partial in 4.1 %, and rejection in 5.9%.
The study findings show a high prevalence of DTRPs due to drug/dose selection and drug use without indication. It seems that the participation of clinical pharmacists in multidisciplinary teams together with the presence of closed loop medication management facilitates the detection and correction of DTRPs.
药物治疗相关问题（DTRP）可能导致可避免的负面健康后果，尤其是在住院期间。本研究旨在评估临床药师干预检测到的DTRP的发生频率、原因及相关因素。
这是一项对2022年9月至2022年12月期间阿联酋法基赫大学医院内科病房收治患者进行的前瞻性横断面研究。收集了临床药师评估的关于DTRP的借口和原因的患者数据，并使用SPSS 27.0版进行分析。
研究了310例平均年龄为33.43±19.98岁的患者（53.9%为男性）。患者中亚洲人占比最高（31.0%），阿拉伯人占比30.6%。79例（25.4%）患者无DTRP，而231例（74.6%）有DTRP。外科病房DTRP的发生频率最高（41.0%）。药物选择不当79例、无适应证用药73例、治疗剂量不足26例是DTRP最常见的原因。饮酒（p = 0.03）、食物过敏（p = 0.02）、31 - 40岁年龄组（p = 0.04）、存在合并症（p = 0.01）、家族病史（p = 0.02）以及入住重症监护病房（ICU）（p = 0.01）是DTRP的显著相关因素。临床药师干预的接受情况为90.0%的病例完全接受，4.1%部分接受，5.9%拒绝。
研究结果表明，由于药物/剂量选择和无适应证用药导致DTRP的患病率较高。临床药师参与多学科团队以及闭环药物管理似乎有助于DTRP的检测和纠正。
