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敲低长链非编码RNA-GAS5可恢复[具体因素]对铜死亡蛋白FDX-1的抑制作用 。 （注：原文中“by.”部分表述不完整，翻译时根据语境补充了“[具体因素]”）

Knocking Down LncRNA-GAS5 Restores the Inhibition of Cuprotosis Protein FDX-1 by .

作者信息

An Zhiyuan, Ding Wenyi

机构信息

Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

出版信息

Pol J Microbiol. 2024 Dec 13;73(4):535-539. doi: 10.33073/pjm-2024-040. eCollection 2024 Dec 1.

DOI:10.33073/pjm-2024-040
PMID:39670641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11639367/
Abstract

This study investigated the regulatory effect of LncRNA-GAS5 on FDX-1 in HEK293T cells by . Transfected LncRNA-GAS5 overexpressing or knocking down plasmids into HEK293T cells, and the expression of FDX-1 was detected by Western blotting. inhibited the expression of FDX-1. Overexpression of LncRNA-GAS5 inhibited the expression of FDX-1, while knocking down LncRNA-GAS5 increased the expression of FDX-1. Overexpression of LncRNA-GAS5 further enhanced the inhibitory effect of on FDX-1, while knocking down LncRNA-GAS5 restored the inhibitory effect of on FDX-1. LncRNA-GAS5 regulates the inhibitory effect of on FDX-1 in HEK293T cells.

摘要

本研究通过将过表达或敲低LncRNA-GAS5的质粒转染至HEK293T细胞中，研究了LncRNA-GAS5对HEK293T细胞中FDX-1的调控作用。通过蛋白质印迹法检测FDX-1的表达。[此处原文缺失相关试剂或因素名称]抑制了FDX-1的表达。LncRNA-GAS5的过表达抑制了FDX-1的表达，而敲低LncRNA-GAS5则增加了FDX-1的表达。LncRNA-GAS5的过表达进一步增强了[此处原文缺失相关试剂或因素名称]对FDX-1的抑制作用，而敲低LncRNA-GAS5则恢复了[此处原文缺失相关试剂或因素名称]对FDX-1的抑制作用。LncRNA-GAS5调节[此处原文缺失相关试剂或因素名称]对HEK293T细胞中FDX-1的抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d513/11639367/a3854767d60c/j_pjm-2024-040_fig_004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d513/11639367/15633a5f9b18/j_pjm-2024-040_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d513/11639367/d013f073e9a0/j_pjm-2024-040_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d513/11639367/127cfe7b53e2/j_pjm-2024-040_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d513/11639367/a3854767d60c/j_pjm-2024-040_fig_004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d513/11639367/15633a5f9b18/j_pjm-2024-040_fig_001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d513/11639367/d013f073e9a0/j_pjm-2024-040_fig_002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d513/11639367/127cfe7b53e2/j_pjm-2024-040_fig_003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d513/11639367/a3854767d60c/j_pjm-2024-040_fig_004.jpg

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Copper induces cell death by targeting lipoylated TCA cycle proteins.
铜通过靶向脂酰化 TCA 循环蛋白诱导细胞死亡。
Science. 2022 Mar 18;375(6586):1254-1261. doi: 10.1126/science.abf0529. Epub 2022 Mar 17.
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up-regulates LncRNA-GAS5 and promotes the degradation of STX17 by blocking the activation of YY1.上调 LncRNA-GAS5，并通过阻断 YY1 的激活来促进 STX17 的降解。
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