Mishnev O D, Raksha A P, Zhukotskiĭ A V, Shchegolev A I
Biull Eksp Biol Med. 1985 Jan;99(1):22-4.
Experimental temporary occlusion of the dog hind limbs was produced. Histoenzymological changes in the liver induced by the temporary ischemia of the limbs and by ischemia with a 2-hour revascularization were subjected to comparative histophotometric examination. The data obtained indicate an appreciable rise in the enzymatic activity of hepatocytes at the early stages of experiments and increasing reduction in metabolic processes at the later stages. A substantial decrease was noted in the activity of the liver enzymes under study, with that decrease being especially pronounced at the later times in experiments with limb revascularization, which is accounted for by a far greater release to the bloodstream of metabolic products from the ischemized limbs.
制造了犬后肢的实验性暂时闭塞。对肢体暂时缺血以及缺血2小时后再灌注所诱导的肝脏组织酶学变化进行了比较组织光度测定检查。所获得的数据表明，在实验早期肝细胞的酶活性显著升高，而在后期代谢过程的减少不断增加。所研究的肝脏酶活性显著降低，在肢体再灌注实验的后期这种降低尤为明显，这是由于缺血肢体代谢产物向血流中的释放量大得多所致。
