Mirzoian R S, Ragimov Kh S, Bespalova Zh D
Biull Eksp Biol Med. 1984 Sep;98(9):308-10.
A tetrapeptidamide nitroanalog and morphine produced an unmarked and short-lived increase in cerebral circulation, determined by the reduction of the vascular tone in both arterial brain systems. The tetrapeptidamide nitroanalog and morphine exerted a pronounced depressant effect on the nervous regulation of cerebral circulation by inhibiting the reflex constriction of the cerebral vessels. These effects of the drugs also occurred under blockade of GABA receptors. This indicates no relationship between the properties of the tetrapeptidamide nitroanalog and morphine and bicuculline-sensitive GABAergic processes.
一种四肽酰胺硝基类似物和吗啡使脑循环出现无明显特征且短暂的增加，这是通过两个脑动脉系统血管张力的降低来确定的。该四肽酰胺硝基类似物和吗啡通过抑制脑血管的反射性收缩，对脑循环的神经调节产生显著的抑制作用。这些药物的这些作用在GABA受体被阻断的情况下也会发生。这表明四肽酰胺硝基类似物和吗啡的特性与荷包牡丹碱敏感的GABA能过程之间没有关系。
