[Induction of drug resistance to sarcolysine in plasmacytoma line MORC/406].

A sarcolysine-resistant strain of mouse plasmacytoma MOPC/406 was obtained in experiments on 250 BALB/c mice. The initial plasmacytoma strain is highly sensitive to sarcolysine. When administered in doses of 10 and 5 mg/kg it increases the lifespan up to 50 days (the observation period). In the course of resistance induction by incremental doses of sarcolysine, a highly resistant plasmacytoma strain was obtained. In the 20th generation of inoculations with the use of sarcolysine administration of 10 mg/kg (intraperitoneally) provided only a 18% increase in the lifespan, whereas the dose 5 mg/kg stimulated the growth of plasmacytoma. The strain obtained preserves its resistance under cryoconservation in liquid nitrogen, being a model that permits one to study resistance, cross-resistance and approaches to its overcoming.