Zhang Yue, Liu Xiaoning, Yang Shaolun, Yang Xueni, Shang Mengmeng, Zhang Yujie, Tian Limin
The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, China.
Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, 730000, China.
Acta Diabetol. 2024 Dec 13. doi: 10.1007/s00592-024-02427-6.
To survey the epidemiology of type 1 diabetes in all age groups living in the Gansu Province, China during 2018-2022.
Using the data from the Gansu Province Health Commission Information Center and medical records, the crude incidence and 95%CI were calculated by region, age group, and sex assuming a Poisson distribution. The incidence differences were evaluated using the χ2 test. Spearman correlation was used to analyze the relation between latitude and incidence. The seasonality was analyzed using concentration, seasonal index and circular distribution method.
1393 cases of newly diagnosed type 1 diabetes were ascertained. The crude incidence of type 1 diabetes per 100,000 person-years in all individuals in Gansu Province was 1.09(95% confidence interval 1.03 to 1.15). The estimated incidence per 100,000 person-years by age group was 1.39 (95%CI:1.24-1.54) for 0-14 years, 3.58 (95%CI:3.33-3.83) for 15-29 years, 0.33(95%CI:0.29-0.37) for ≥ 30 years, with a peak in age group 15-19 years. There was a difference between males and females. Incidence of type 1 diabetes in Gansu Province was strongly correlated with latitude among children aged 0-29 years, and all age groups, but such correlation was not observed in adults aged ≥ 30 years. The seasonality of the type 1 diabetes is not obvious.
The incidence of type 1 diabetes was relatively lower from 2018 to 2022 in Gansu Province, with variations across different regions and a positive correlation with latitude observed in all age groups. The incidence peak was noted in the 15-19 years group, and the incidence among males was higher than in females in all age groups. There was no significant seasonal variation in the incidence of type 1 diabetes.
调查2018 - 2022年中国甘肃省所有年龄组1型糖尿病的流行病学情况。
利用甘肃省卫生健康委员会信息中心的数据和医疗记录，假设为泊松分布，按地区、年龄组和性别计算粗发病率及95%置信区间（CI）。采用χ2检验评估发病率差异。用Spearman相关性分析纬度与发病率之间的关系。采用集中度、季节指数和圆形分布法分析季节性。
确诊1393例新诊断的1型糖尿病病例。甘肃省所有人群中1型糖尿病的粗发病率为每10万人年1.09（95%置信区间1.03至1.15）。按年龄组估计的每10万人年发病率，0 - 14岁为1.39（95%CI：1.24 - 1.54），15 - 29岁为3.58（95%CI：3.33 - 3.83），≥30岁为0.33（95%CI：0.29 - 0.37），发病高峰在15 - 19岁年龄组。男性和女性之间存在差异。甘肃省0 - 29岁儿童及所有年龄组的1型糖尿病发病率与纬度密切相关，但≥30岁成年人中未观察到这种相关性。1型糖尿病的季节性不明显。
2018年至2022年甘肃省1型糖尿病发病率相对较低，不同地区存在差异，所有年龄组发病率与纬度呈正相关。发病高峰出现在15 - 19岁年龄组，所有年龄组男性发病率均高于女性。1型糖尿病发病率无明显季节性变化。
