Wu Kefan, Lu Lifei, Chen Yubiao, Peng Jieqi, Wu Xiaohui, Tang Gaoying, Ma Ting, Cheng Jing, Ran Pixin, Zhou Yumin
Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Guangzhou National Laboratory, Bio-Island, Guangzhou, China.
Pulmonology. 2025 Dec 31;31(1):2438553. doi: 10.1080/25310429.2024.2438553. Epub 2024 Dec 13.
The associations between anxiety, depression, and the prognosis of COPD remain uncertain. The present study aims to investigate the associations of anxiety and depression with 30-day readmission rates and acute exacerbations of COPD (AECOPD). Four databases were searched to identify relevant studies published before 13 March 2024. Studies that report on the impact of anxiety and depression on the prognosis of AECOPD were included. The pooled effect size and its 95% confidence interval (CI) were calculated using a random effects model. The primary outcomes were 30-day readmission and AECOPD within the first year after discharge in COPD patients. Of the 5,955 studies screened, 14 studies were included in the analysis. Patients with anxiety had a higher risk of AECOPD within the first year after discharge compared to those without anxiety (HR: 2.10, 95% CI: 1.28-3.45, = 0.003). Patients with depression also had a higher risk of AECOPD within the first year after discharge (HR: 1.36, 95% CI: 1.10-1.69, = 0.004). Similar results were observed in the associations of anxiety and depression with 30-day readmission. Our results suggested that anxiety and depression were associated with an increased risk of 30-day readmission and AECOPD in patients with COPD.
焦虑、抑郁与慢性阻塞性肺疾病（COPD）预后之间的关联仍不明确。本研究旨在调查焦虑和抑郁与COPD患者30天再入院率及慢性阻塞性肺疾病急性加重（AECOPD）之间的关联。检索了四个数据库，以识别2024年3月13日前发表的相关研究。纳入了报告焦虑和抑郁对AECOPD预后影响的研究。使用随机效应模型计算合并效应量及其95%置信区间（CI）。主要结局为COPD患者出院后第一年内的30天再入院率和AECOPD。在筛选的5955项研究中，14项研究纳入分析。与无焦虑的患者相比，焦虑患者出院后第一年内发生AECOPD的风险更高（风险比：2.10，95%CI：1.28 - 3.45，P = 0.003）。抑郁患者出院后第一年内发生AECOPD的风险也更高（风险比：1.36，95%CI：1.10 - 1.69，P = 0.004）。在焦虑和抑郁与30天再入院率的关联中也观察到了类似结果。我们的结果表明，焦虑和抑郁与COPD患者30天再入院率和AECOPD风险增加有关。
