Vaughan Megan, Tay Nicole, Kalitzeos Angelos, Kane Thomas, Singh Nav, Zheng Adrian, Dixit Mira, Pal Bishwanath, Rajendram Ranjan, Balaskas Konstantinos, Martin Gutierrez Mari Pilar, Artiaga Jose Carlo, Koutsocheras Georgios, Adan Khadra, Rodriguez-Carmona Marisa, Barbur John L, Michaelides Michel, Patterson Emily J
UCL Institute of Ophthalmology, University College London, London, England, United Kingdom.
Moorfields Eye Hospital NHS Foundation Trust, London, England, United Kingdom.
Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):28. doi: 10.1167/iovs.65.14.28.
Although it is well known that photoreceptor damage and color vision loss occur in patients with diabetic retinopathy (DR), the relationship between structural and functional changes in diabetes mellitus (DM) remains unclear. Using highly sensitive measures of photoreceptor structure and function, we aim to determine whether early loss of color sensitivity in DM is also accompanied by decreased cone density.
Monocular data from 26 patients with DM and 25 healthy controls were examined to assess cone photoreceptor metrics, using confocal adaptive optics scanning light ophthalmoscopy, and red/green (RG) and yellow/blue (YB) color vision thresholds, using the Colour Assessment and Diagnosis test.
Both RG and YB thresholds were significantly greater in patients with DM than in the healthy controls (RG and YB = P < 0.001), and there were statistically significant differences between the 2 groups in confocal cone density at 1 degree (P = 0.024), and intercell regularity at both 1 (P = 0.013) and 2 degrees (P = 0.012). In patients with DM, cone density was inversely correlated with YB (at 0.5, 1 and 2 degrees, all P values < 0.041), but not for RG color vision thresholds.
This is the first study to investigate the relationship between cone metrics and color vision in patients with DM. The results reveal a significant inverse relationship between confocal cone density and color vision thresholds at the locations assessed within the foveal region. These findings represent a significant advancement in oculomics research.
虽然众所周知糖尿病性视网膜病变（DR）患者会出现光感受器损伤和色觉丧失，但糖尿病（DM）患者结构和功能变化之间的关系仍不清楚。我们旨在通过使用高灵敏度的光感受器结构和功能测量方法，确定DM患者早期色觉敏感度丧失是否也伴随着视锥细胞密度降低。
使用共焦自适应光学扫描激光检眼镜检查26例DM患者和25例健康对照者的单眼数据，以评估视锥光感受器指标，并使用颜色评估与诊断测试评估红/绿（RG）和黄/蓝（YB）色觉阈值。
DM患者的RG和YB阈值均显著高于健康对照者（RG和YB = P < 0.001），两组在1度处的共焦视锥细胞密度（P = 0.024）以及1度（P = 0.013）和2度（P = 0.012）处的细胞间规则性存在统计学显著差异。在DM患者中，视锥细胞密度与YB呈负相关（在0.5、1和2度处，所有P值< 0.041），但与RG色觉阈值无关。
这是第一项研究DM患者视锥细胞指标与色觉之间关系的研究。结果显示在黄斑区域评估的位置，共焦视锥细胞密度与色觉阈值之间存在显著的负相关。这些发现代表了眼组学研究的重大进展。
