Shen Xuejing, Jia Erwen, Huang Yin, Ge Dingbang, Sun Zheng, Yang Zhiyan, Zhang Ping, Chen Yihao, Feng Xue
Laboratory of Flexible Electronics Technology, Tsinghua University, Beijing, 100084, China.
AML, Department of Engineering Mechanics, Tsinghua University, Beijing, 100084, China.
Sci Adv. 2024 Dec 13;10(50):eadq5822. doi: 10.1126/sciadv.adq5822.
Atrial fibrillation leads to severe diseases such as heart failure and strokes. While catheter ablation is prevalent for the treatment, existing techniques hardly can achieve both tissue selectivity and ablation uniformity. Here, we propose a bioinspired strategy for balloon-based pulsed field ablation (PFA) systems based on "flounder" electrodes. Inspired by a flounder skeleton and citrus peels, the microfabricated electrodes are ultrathin, stretchable, and have a scattered configuration, withstanding large balloon deformation (87% compression), high voltage (1200 volts), and owning exceptional tissue conformability (720° twists). Mechanical-electrical coupled stimulation optimizes balloon electrodes with hemispherical electric field uniformity. A water lily-inspired transfer printing method enables one-step integration of multielectrodes with the balloon. A comprehensive PFA system is complemented, achieving ablation depths of 3.8 millimeters (potato), 3.1 millimeters (rabbit), and 2.3 millimeters (swine) with good uniformity and electrophysiological isolation. These results shed light on the quantitative design of PFA systems, with high potential for more precise, safe, and effective catheter ablation therapies.
心房颤动会引发诸如心力衰竭和中风等严重疾病。虽然导管消融是治疗该病的常用方法，但现有技术很难同时实现组织选择性和消融均匀性。在此，我们基于“比目鱼”电极提出了一种用于基于球囊的脉冲场消融（PFA）系统的仿生策略。受比目鱼骨骼和柑橘皮的启发，微纳加工的电极超薄、可拉伸且具有分散的结构，能够承受较大的球囊变形（87%压缩）、高电压（1200伏），并具有出色的组织贴合性（720°扭转）。机电耦合刺激优化了具有半球形电场均匀性的球囊电极。一种受睡莲启发的转移印刷方法实现了多电极与球囊的一步集成。完善了一个综合的PFA系统，在土豆、兔子和猪身上分别实现了3.8毫米、3.1毫米和2.3毫米的消融深度，且具有良好的均匀性和电生理隔离效果。这些结果为PFA系统的定量设计提供了思路，在更精确、安全和有效的导管消融治疗方面具有很高的潜力。
