炎症性肠病成年患者腹痛、疲劳及心理症状的性别差异：一项网络分析
Gender and Sex Differences in Abdominal Pain, Fatigue, And Psychological Symptoms Among Adults with Inflammatory Bowel Disease: A Network Analysis.
作者信息
Kamp Kendra, Yang Pei-Lin, Tsai Chi-Shan, Zhang Xiaoyu, Yoo Linda, Altman Molly R, Heitkemper Margaret, Conley Samantha, Kane Sunanda, Winders Samantha
机构信息
Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington, Seattle, WA, USA.
National Defense Medical Center, Taipei, Taiwan.
出版信息
Inflamm Bowel Dis. 2025 Feb 10;31(2):442-449. doi: 10.1093/ibd/izae279.
BACKGROUND AND AIMS
Individuals with inflammatory bowel disease (IBD) experience a high symptom burden, including abdominal pain, fatigue, anxiety, depression, and sleep disturbances; yet, little is known regarding the relationship between sex and gender on symptoms. We sought to report symptom severity for cisgender men, cisgender women, and transgender and gender-diverse (TGD) individuals. In addition, we used network analysis to identify core symptoms and explore if symptoms and their relationships differ between cisgender men and cisgender women.
METHODS
This was a cross-sectional study. We recruited adults with IBD online through ResearchMatch. Individuals responded to Patient-Reported Outcomes Measurement Information symptom questionnaires, as well as demographic and clinical questionnaires. Network analysis was used to identify the core symptoms driving the symptom structure.
RESULTS
One-hundred and fifty-seven (63.3%) participants identified as cisgender women, 84 (33.9%) as cisgender men, and 7 (2.8%) as TGD. Cisgender men (M = 61.8) and TGD (M = 61.3) groups reported higher abdominal pain levels compared with cisgender women (M = 57.8; P = .02). Transgender and gender-diverse individuals reported higher depression levels (M = 64.8) compared with cisgender men (M = 56.7) and cisgender women (M = 54.4; P = .01). Using a network analysis approach, anxiety and fatigue emerged as core symptoms for the entire sample (clinically active and inactive disease), and among only those with active clinical disease. Fatigue was a top core symptom for cisgender women; anxiety emerged as a top core symptom for cisgender men.
CONCLUSIONS
This study highlights that fatigue and anxiety are core symptoms among individuals with IBD and demonstrates a potential sex and/or gender difference in core symptoms. Replication of this study is needed with further consideration of inclusion of TGD patients.
背景与目的
炎症性肠病（IBD）患者承受着较高的症状负担，包括腹痛、疲劳、焦虑、抑郁和睡眠障碍；然而，关于症状方面的性别关系却知之甚少。我们试图报告顺性别男性、顺性别女性以及跨性别和性别多样化（TGD）个体的症状严重程度。此外，我们使用网络分析来确定核心症状，并探讨顺性别男性和顺性别女性之间的症状及其关系是否存在差异。
方法
这是一项横断面研究。我们通过ResearchMatch在线招募患有IBD的成年人。参与者回答了患者报告的结局测量信息症状问卷以及人口统计学和临床问卷。网络分析用于确定驱动症状结构的核心症状。
结果
157名（63.3%）参与者被认定为顺性别女性，84名（33.9%）为顺性别男性，7名（2.8%）为TGD。与顺性别女性（M = 57.8；P = 0.02）相比，顺性别男性（M = 61.8）和TGD组（M = 61.3）报告的腹痛水平更高。与顺性别男性（M = 56.7）和顺性别女性（M = 54.4；P = 0.01）相比，跨性别和性别多样化个体报告的抑郁水平更高（M = 64.8）。使用网络分析方法，焦虑和疲劳成为整个样本（临床活动期和非活动期疾病）以及仅临床活动期疾病患者的核心症状。疲劳是顺性别女性的首要核心症状；焦虑是顺性别男性的首要核心症状。
结论
本研究强调疲劳和焦虑是IBD患者的核心症状，并表明核心症状可能存在性别差异。需要进一步考虑纳入TGD患者来重复本研究。
Zotero 插件