Liu Jing, Shao Ziyang, Liu Liyuan, Zhao Qinke, Yang Yongzhen, Niu Mei, Zhang Li, Xue Baoxia
College of Textile Engineering, Taiyuan University of Technology, Taiyuan 030024, People's Republic of China.
Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, People's Republic of China.
Biomed Mater. 2024 Dec 30;20(1). doi: 10.1088/1748-605X/ad9f03.
To endow silicone rubber (SR) catheter with antibacterial property, the SR catheter was modified with a new kind of biomass carbon dots (CDs) by the bulk modification to obtabin the SR/CDs catheter. The antimicrobial behavior and biocompatibility of SR/CDs catheter were analyzed by plate counting method, cytotoxicity test andanimal experiments. The results showed that, SR/CDs catheter possessed antimicrobial properties, and the minimum inhibitory concentration of SR/CDs catheter was 20 mg mlagainstand. The antimicrobial mechanism of SR/CDs was further investigated, and it was found that the SR/CDs induced the production of reactive oxygen species in bacterial cells by disrupting the bacterial membrane through adsorption. In addition,experiments have shown that SR/CDs catheter owns good biosafety profile and reduces the risk of catheter-associated urinary tract infections by modulating inflammatory factors. Meanwhile, SR/CDs catheter can be produced in a simple production process using an extruder, which is expected to be used as a novelty type of catheter in the clinic.
为赋予硅橡胶（SR）导管抗菌性能，通过本体改性用一种新型生物质碳点（CDs）对SR导管进行改性，以获得SR/CDs导管。采用平板计数法、细胞毒性试验和动物实验分析了SR/CDs导管的抗菌行为和生物相容性。结果表明，SR/CDs导管具有抗菌性能，其最低抑菌浓度为20mg/ml。进一步研究了SR/CDs的抗菌机制，发现SR/CDs通过吸附破坏细菌细胞膜，诱导细菌细胞产生活性氧。此外，实验表明，SR/CDs导管具有良好的生物安全性，通过调节炎症因子降低了导管相关尿路感染的风险。同时，SR/CDs导管可以使用挤出机通过简单的生产工艺制备，有望在临床上用作新型导管。
