液体活检的进展：从探索到实际应用。

Advances in liquid biopsy: From exploration to practical application.

作者信息

Alix-Panabières Catherine, Pantel Klaus

机构信息

Laboratory of Rare Human Circulating Cells (LCCRH) and Liquid Biopsy, University Medical Centre of Montpellier, Montpellier, France; CREEC (CREES), Unité Mixte de Recherches, IRD 224-CNRS 5290-Université de Montpellier, Montpellier, France; European Liquid Biopsy Society (ELBS), Hamburg, Germany; Department of Tumor Biology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.

European Liquid Biopsy Society (ELBS), Hamburg, Germany; Department of Tumor Biology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.

出版信息

Cancer Cell. 2025 Feb 10;43(2):161-165. doi: 10.1016/j.ccell.2024.11.009. Epub 2024 Dec 12.

DOI:10.1016/j.ccell.2024.11.009

PMID:39672165

Abstract

Liquid biopsy has received tremendous attention as a non-invasive approach for detecting and tracking cancer. Here, we discuss the latest work on circulating tumor DNA and circulating tumor cells with respect to clinical applications, including cancer screening, early detection of relapse, real-time monitoring of therapeutic efficacy, and detection of therapeutic targets and resistance mechanisms.

摘要

液体活检作为一种检测和追踪癌症的非侵入性方法受到了极大关注。在此，我们讨论关于循环肿瘤DNA和循环肿瘤细胞在临床应用方面的最新研究成果，包括癌症筛查、复发的早期检测、治疗疗效的实时监测以及治疗靶点和耐药机制的检测。