Zhong Yuke, Liu Ying, Su Huahua, Liu Hang, Liu Guohui, Liu Zhihui, Wei Jiahao, Wang Junyi, She Yuchen, Tan Changhong, Mo Lijuan, Han Lin, Deng Fen, Liu Xi, Chen Lifen
Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, China.
Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, China.
Brain Res Bull. 2025 Jan;220:111169. doi: 10.1016/j.brainresbull.2024.111169. Epub 2024 Dec 11.
Resting tremor in Parkinson's disease (PD) is associated with the activity in the basal ganglia and cerebello-thalamo-cortical circuits/network. However, most insights stem from functional MRI research, and structural studies, which can provide basis for and constrain functional activity, remains limited.
We investigated the structural change in PD patients with resting tremor (PD-WR) from a network perspective. 42 early-stage PD-WR, 27 PD patients without resting tremor (PD-NR), and 56 healthy controls (HC) were included.
PD-WR showed lower cortical thickness in several motor-related lobules. Compared to HC, significant atrophy was found in right lobule VIIA (t = -3.076, p = 0.016, Cohen's d = 0.627), left lobule VI (t = -3.323, p = 0.007, Cohen's d = 0.678), and right lobule VI (t = -3.052, p = 0.017, Cohen's d = 0.623) in PD-WR. Compared to PD-NR, left lobule V also had a significant reduction (t = -2.958, p = 0.023, d = -0.657). PD-WR had higher fractional anisotropy in cerebello-cortical connection compared to HC (t = 3.209, p = 0.009, d = 0.926), with reduced radial (t = -2.561, p = 0.046, d = 0.739) and mean (t = 2.614, p = 0.046, d = 0.871) diffusivity compared to PD-NR. At the network level, better hierarchy (rho = 0.598, p = 0.004), small-worldness (rho = 0.621, p = 0.003), and increased nodal involvement of the thalamus (rho = 0.718, p = 0.031) and motor cortex (rho = 0.660, p = 0.055) were positively correlated with tremor amplitude.
Our study supports the alternation of the cerebello-thalamo-cortical circuit in PD-WR. However, further research with other forms of PD, a wide range of disease stage and larger sample size is needed.
帕金森病（PD）的静止性震颤与基底神经节以及小脑 - 丘脑 - 皮质回路/网络的活动有关。然而，大多数见解源于功能磁共振成像研究，而能够为功能活动提供基础并限制其活动的结构研究仍然有限。
我们从网络角度研究了伴有静止性震颤的PD患者（PD - WR）的结构变化。纳入了42例早期PD - WR患者、27例无静止性震颤的PD患者（PD - NR）和56名健康对照者（HC）。
PD - WR在几个与运动相关的脑叶中皮质厚度较低。与HC相比，PD - WR患者右侧VIIA小叶（t = -3.076，p = 0.016，Cohen's d = 0.627）、左侧VI小叶（t = -3.323，p = 0.007，Cohen's d = 0.678）和右侧VI小叶（t = -3.052，p = 0.017，Cohen's d = 0.623）出现明显萎缩。与PD - NR相比，左侧V小叶也有显著减少（t = -2.958，p = 0.023，d = -0.657）。与HC相比，PD - WR患者小脑 - 皮质连接的分数各向异性更高（t = 3.209，p = 0.009，d = 0.926），与PD - NR相比，其径向（t = -2.561，p = 0.046，d = 0.739）和平均（t = 2.614，p = 0.046，d = 0.871）扩散率降低。在网络层面，更好的层级性（rho = 0.598，p = 0.004）、小世界特性（rho = 0.621，p = 0.003）以及丘脑（rho = 0.718，p = 0.031）和运动皮层（rho = 0.660，p = 0.055）节点参与度的增加与震颤幅度呈正相关。
我们的研究支持PD - WR中小脑 - 丘脑 - 皮质回路的改变。然而，需要对其他形式的PD、更广泛的疾病阶段和更大样本量进行进一步研究。
