Zabala-Gómez Oihana, Ibarretxe-Bilbao Naroa, Tijero Beatriz, Gabilondo Iñigo, Peña Javier, Ojeda Natalia, Zubiaurre-Elorza Leire, Acera Marian, Pino Rocío Del, Gómez-Esteban Juan Carlos, Lucas-Jiménez Olaia
Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Spain.
Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Spain.
Neuroscience. 2025 Jul 23;579:122-128. doi: 10.1016/j.neuroscience.2025.06.001. Epub 2025 Jun 3.
Fatigue is a nonmotor symptom that negatively affects Parkinson's disease (PD) patients' quality of life. The study of fatigue is complex and the brain functional neural underpinnings of fatigue in PD are yet to be clarified. The aim of this study was to investigate the functional connectivity (FC) of the fatigue brain network in PD-related fatigue symptomatology. Forty-nine PD patients, divided into PD patients with fatigue (PD-f) and PD patients with no fatigue (PD-nf), and 33 healthy controls participated in the study. Participants completed the Fatigue Severity Scale for the assessment of fatigue and underwent an extensive neuropsychological battery. Functional magnetic resonance imaging was also obtained during resting-state. FC differences were studied using a whole-brain analysis with CONN Functional Connectivity Toolbox. The PD-f group showed lower FC between left dorsolateral prefrontal cortex and right accumbens (reward network), and higher FC between the left insula and left posterior parahippocampal gyrus (interoceptive paralimbic area) compared to the PD-nf group. Fatigue was positively correlated with the FC between the left insula and the left posterior parahippocampal gyrus in PD. Hypoactivation in the reward network and hyperactivation in the interoceptive-paralimbic areas may be underlying factors in fatigue symptomatology in PD. In fact, fatigue was found to be correlated with FC in interoceptive-paralimbic areas. These results contribute to a better understanding of the underlying neural mechanisms of the fatigue brain network in PD patients.
疲劳是一种非运动症状，会对帕金森病（PD）患者的生活质量产生负面影响。对疲劳的研究很复杂，PD患者疲劳的脑功能神经基础尚待阐明。本研究的目的是调查PD相关疲劳症状中疲劳脑网络的功能连接（FC）。49名PD患者，分为有疲劳的PD患者（PD-f）和无疲劳的PD患者（PD-nf），以及33名健康对照者参与了研究。参与者完成了疲劳严重程度量表以评估疲劳，并接受了广泛的神经心理测试。在静息状态下也进行了功能磁共振成像。使用CONN功能连接工具箱进行全脑分析研究FC差异。与PD-nf组相比，PD-f组左侧背外侧前额叶皮质与右侧伏隔核（奖赏网络）之间的FC较低，左侧脑岛与左侧海马旁回后部（内感受性边缘旁区域）之间的FC较高。在PD中，疲劳与左侧脑岛和左侧海马旁回后部之间的FC呈正相关。奖赏网络的低激活和内感受性边缘旁区域的高激活可能是PD疲劳症状的潜在因素。事实上，发现疲劳与内感受性边缘旁区域的FC相关。这些结果有助于更好地理解PD患者疲劳脑网络的潜在神经机制。
