Gu MinQi, Zhang DongDong, Wu YuYing, Li Xi, Liang JinLiang, Su YaQin, Yang Li, Chen TaiFeng, Guo BoTang, Zhao Yang, Fu XueRu, Wen LiuDing, Lu ChuXia, Chen YuKe, Huang WanHe, Qin Pei, Hu FuLan, Hu DongSheng, Zhang Ming
Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Medical School, Shenzhen, Guangdong, PR China.
Department of General Practice, The Affiliated Luohu Hospital of Shenzhen University Medical School, Shenzhen, PR China.
Nutr Metab Cardiovasc Dis. 2025 Mar;35(3):103791. doi: 10.1016/j.numecd.2024.103791. Epub 2024 Nov 12.
Although existing evidence suggests that arterial stiffness and obesity impact cardiovascular health, limited studies have been conducted to explore the association between brachial-ankle pulse wave velocity (baPWV), obesity-related indices, and the risk of atherosclerotic cardiovascular disease (ASCVD).
The study participants were among those who completed the baPWV measurement at the second follow-up examination (during 2018-2020) of the Rural Chinese Cohort Study. Logistic regression models were employed to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) of the 10-year incident risk score of ASCVD associated with baPWV and obesity-related indices. Mediation analysis was applied to investigate the role of baPWV in the obesity-induced 10-year incident risk score of ASCVD. A total of 1589 individuals, including 573 men and 1016 women, were included in the study. In logistic regression analyses, the highest quartile levels of baPWV and obesity-related indices all significantly increased the 10-year incident risk score of ASCVD compared to their corresponding lowest quartiles. The ORs (95%CIs) of ASCVD 10-year incident risk score risk were 4.21(2.55-6.94) for baPWV, 4.43(2.69-7.29) for METS-VF, 7.20(4.09-12.66) for CVAI, 3.38(2.12-5.38) for CI, and 2.40(1.54-3.75) for ABSI. The indirect effect of baPWV accounted for 5.85 %, 7.92 %, 14.56 %, and 5.08 % of the total effects for METS-VF, CVAI, CI, and ABSI, respectively.
This study found that elevated levels of both baPWV and obesity-related indices were associated with a higher 10-year incident risk score of ASCVD. Additionally, baPWV partially mediated the obesity-related increase in 10-year incident risk score of ASCVD.
尽管现有证据表明动脉僵硬度和肥胖会影响心血管健康，但探索臂踝脉搏波速度（baPWV）、肥胖相关指标与动脉粥样硬化性心血管疾病（ASCVD）风险之间关联的研究有限。
研究参与者来自中国农村队列研究第二次随访检查（2018 - 2020年期间）中完成baPWV测量的人群。采用逻辑回归模型计算与baPWV和肥胖相关指标相关的ASCVD 10年发病风险评分的比值比（OR）和95%置信区间（CI）。应用中介分析来研究baPWV在肥胖诱导的ASCVD 10年发病风险评分中的作用。该研究共纳入1589人，其中男性573人，女性1016人。在逻辑回归分析中，与相应最低四分位数相比，baPWV和肥胖相关指标的最高四分位数水平均显著增加了ASCVD的10年发病风险评分。baPWV的ASCVD 10年发病风险评分风险的OR（95%CI）为4.21（2.55 - 6.94），代谢当量 - 内脏脂肪（METS - VF）为4.43（2.69 - 7.29），心血管健康指数（CVAI）为7.20（4.09 - 12.66），颈围指数（CI）为3.38（2.12 - 5.38），体脂率指数（ABSI）为2.40（1.54 - 3.75）。baPWV的间接效应分别占METS - VF、CVAI、CI和ABSI总效应的5.85%、7.92%、14.56%和5.08%。
本研究发现，baPWV和肥胖相关指标水平升高均与ASCVD更高的10年发病风险评分相关。此外，baPWV部分介导了肥胖相关的ASCVD 10年发病风险评分升高。
