Department of Cardiovascular Disease, Peking University First Hospital, Beijing, China.
Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, China.
J Clin Hypertens (Greenwich). 2023 Mar;25(3):278-285. doi: 10.1111/jch.14642. Epub 2023 Feb 15.
Accumulated evidence has shown that carotid-femoral and brachial-ankle PWV well predict cardiovascular events but it is still unclear if the predictability is same or not. In this cross-sectional study based on a community atherosclerosis cohort in Beijing, China, a total of 5282 participants without previous coronary heart disease and stroke were enrolled from a community atherosclerosis cohort in Beijing, China. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk were calculated by the China-PAR model, and < 5%, 5%-10% and > 10% were defined as low, intermediate, and high risk, respectively. The average baPWV and cfPWV values were 16.63 ± 3.35 m/s and 8.45 ± 1.78 m/s, respectively. The mean 10-year ASCVD risk was 6.98% (interquartile range: 3.90%-12.01%). The patients with low, intermediate, and high 10-year ASCVD risk accounted for 34.84% (1840), 31.94% (1687),, and 33.23% (1755) respectively. Multivariate analysis showed that for every 1 m/s increase in baPWV and cfPWV, the 10-year ASCVD risk increased by 0.60% (95% confidence interval: 0.56%-0.65%, p < .001) and 1.17% (95% confidence interval: 1.09%-1.25%, p < .001), respectively. The diagnostic ability of the baPWV was comparable to the cfPWV (area under the curve: 0.870 [0.860-0.879] vs. 0.871 [0.861-0.881], p = .497). In conclusion, baPWV and cfPWV are positively associated with the 10-year risk of ASCVD in the Chinese community-based population, with a nearly identical association with a high 10-year risk of ASCVD.
已有大量证据表明，颈股动脉脉搏波速度和臂踝动脉脉搏波速度可很好地预测心血管事件，但两者的预测能力是否相同尚不清楚。本研究为基于中国北京社区动脉粥样硬化队列的横断面研究，共纳入 5282 名无冠心病和卒中史的参与者。采用中国动脉粥样硬化性心血管疾病风险预测模型计算 10 年 ASCVD 风险，低危、中危和高危分别定义为风险<5%、5%-10%和>10%。平均 baPWV 和 cfPWV 值分别为 16.63±3.35 m/s 和 8.45±1.78 m/s。平均 10 年 ASCVD 风险为 6.98%（四分位间距：3.90%-12.01%）。低、中、高危 10 年 ASCVD 风险患者分别占 34.84%（1840 例）、31.94%（1687 例）和 33.23%（1755 例）。多变量分析显示，baPWV 和 cfPWV 每增加 1 m/s，10 年 ASCVD 风险分别增加 0.60%（95%置信区间：0.56%-0.65%，p<0.001）和 1.17%（95%置信区间：1.09%-1.25%，p<0.001）。baPWV 对 10 年 ASCVD 风险的诊断能力与 cfPWV 相当（曲线下面积：0.870[0.860-0.879] 比 0.871[0.861-0.881]，p=0.497）。综上，在中国社区人群中，baPWV 和 cfPWV 与 10 年 ASCVD 风险呈正相关，与高风险 10 年 ASCVD 风险的相关性几乎相同。
