食用奇亚籽（西班牙鼠尾草）对成年人血压和身体成分的影响：随机对照试验的系统评价和荟萃分析

The Effects of Chia Seed (Salvia hispanica L.) Consumption on Blood Pressure and Body Composition in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

作者信息

Saadh Mohamed J, Abosaoda Munthar Kadhim, Baldaniya Lalji, Kalia Rishiv, Arya Renu, Mishra Shivang, Chauhan Ashish Singh, Kumar Abhinav, Alizadeh Mohamad

机构信息

Faculty of Pharmacy, Middle East University, Amman, Jordan.

College of Pharmacy, The Islamic University, Najaf, Iraq; College of Pharmacy, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq; College of Pharmacy, The Islamic University of Babylon, Babylon, Iraq.

出版信息

Clin Ther. 2025 Feb;47(2):168-175. doi: 10.1016/j.clinthera.2024.11.012. Epub 2024 Dec 12.

DOI:10.1016/j.clinthera.2024.11.012

PMID:39672763

Abstract

PURPOSE

Growing evidence has suggested that the consumption of chia seed can decrease blood pressure and obesity in adults. However, even studies have reported uncertain findings. The current meta-analysis aimed to assess the findings of randomized controlled trials (RCTs) on the efficacy of chia seed supplementation on blood pressure (systolic blood pressure [SBP], diastolic blood pressure [DBP]) and body composition (waist circumference [WC], weight, body mass index [BMI]) in adults.

METHODS

A systematic search of the literature was carried out in the PubMed, Web of Knowledge, Scopus, Cochrane Central Library, and EMBASE from inception up to October 2024. Data were extracted and analyzed using a random-effects model, and reported as weighted mean differences (WMD) with 95% confidence intervals (CI).

FINDINGS

A total of eight RCTs involving 372 participants were included in the meta-analysis. The results showed that chia consumption significantly reduced DBP (WMD: -7.49 mmHg; 95% CI: -9.64, -5.34; P < 0.001) and SBP (WMD: -5.61 mmHg; 95% CI: -8.77, -2.44; P = 0.001). Moreover, consuming chia seeds was linked to a notable decrease in WC (WMD: -1.46 cm; 95% CI: -2.68, -0.25; P = 0.01), but it had no significant effect on, BMI (WMD: -0.31 kg/m; 95% CI: - 0.96, 0.34; P = 0.34) and weight (WMD: 0.09 kg; 95% CI: -0.76, 0.93; P = 0.84).

IMPLICATIONS

Chia consumption can significantly reduce SBP, DBP, and WC in adults, but no significant impact was showed on BMI and weight. To verify these results, more studies involving a greater number of participants are required.

摘要

目的

越来越多的证据表明，食用奇亚籽可以降低成年人的血压和肥胖水平。然而，即便有研究报告了不确定的结果。当前的荟萃分析旨在评估随机对照试验（RCT）关于补充奇亚籽对成年人血压（收缩压[SBP]、舒张压[DBP]）和身体成分（腰围[WC]、体重、体重指数[BMI]）影响的研究结果。

方法

从创刊至2024年10月，在PubMed、Web of Knowledge、Scopus、Cochrane Central Library和EMBASE中对文献进行系统检索。使用随机效应模型提取和分析数据，并报告为加权平均差（WMD）及95%置信区间（CI）。

结果

共有八项涉及372名参与者的随机对照试验纳入了荟萃分析。结果显示，食用奇亚籽可显著降低舒张压（WMD：-7.49 mmHg；95% CI：-9.64，-5.34；P < 0.001）和收缩压（WMD：-5.61 mmHg；95% CI：-8.77，-2.44；P = 0.001）。此外，食用奇亚籽与腰围显著降低有关（WMD：-1.46 cm；95% CI：-2.68，-0.25；P = 0.01），但对体重指数（WMD：-0.31 kg/m；95% CI：- 0.96，0.34；P = 0.34）和体重（WMD：0.09 kg；95% CI：-0.76，0.93；P = 0.84）无显著影响。