咖啡摄入量与中风高发患者更好的认知表现相关。

Coffee Consumption Correlates With Better Cognitive Performance in Patients With a High Incidence for Stroke.

作者信息

Barbagallo Massimo, Springer Anne, Vanetta Chiara, Allemann Meret, Lee Pratintip, Saeedi Soheil, Aeschbacher Stefanie, Luciani Marco, Bonati Leo H, Moschovitis Giorgio, Scheu Victor, Rutishauser Jonas, Kobza Richard, Di Valentino Marcello, Meyre Pascal B, Rodondi Nicolas, Conen David, Kühne Michael, Osswald Stefan, Beer Jürg H

机构信息

Department of Internal Medicine Cantonal Hospital of Baden Baden Switzerland.

Institute of Intensive Care Medicine University Hospital Zurich Zurich Switzerland.

出版信息

J Am Heart Assoc. 2025 Jan 7;14(1):e034365. doi: 10.1161/JAHA.124.034365. Epub 2024 Dec 14.

DOI:10.1161/JAHA.124.034365

PMID:39673298

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12054421/

Abstract

BACKGROUND

Atrial fibrillation is an independent risk factor for the development of cognitive impairments. Regular coffee consumption has shown cognitive benefits in healthy individuals. Whether regular consumption reduces cognitive decline in vulnerable patients is controversial. We investigated the association in elderly people with atrial fibrillation.

METHODS AND RESULTS

Daily coffee consumption was assessed using a structured nutrition questionnaire, and cognitive function was evaluated by a detailed neurocognitive-test-battery, including the Montreal Cognitive Assessment, Trail-Making Test, semantic fluency, and Digit-Symbol-Substitution Test. The cognitive construct score combines all neurocognitive tests mentioned and provides an overall cognitive performance indicator. Hs-CRP (high-sensitivity C-reactive protein) and IL-6 (interleukin-6) were measured to explore an association with inflammation. Results were estimated using linear mixed-effects-models with detailed adjustments for confounders. The <1 cup/day consumers (reference group) reached a cognitive construct score of -0.24 (95% CI, -0.27 to -0.16), and the group with the highest consumption (>5 cups/day) was at -0.10 (95% CI, -0.10 to 0.04; =0.048). Montreal Cognitive Assessment score in the reference group was 24.58 (95% CI, 24.58-25.32); the group with the highest intake achieved 25.25 (95% CI, 24.98-26.85; =0.163). Inflammatory markers decreased with higher coffee consumption (hs-CRP with 5 compared with <1 cup/day by factor 0.78 [95% CI, 0.54-1.13], = 0.188, IL-6 significantly by factor 0.73 [95% CI, 0.57-0.95], =0.017).

CONCLUSIONS

Coffee consumption in patients with atrial fibrillation may be associated with improved cognitive performance and reduced inflammatory markers. Further research is needed to confirm these findings and to consider implementation in dietary counseling for atrial fibrillation management.

REGISTRATION

URL: https://www.clinicaltrials.gov; Identifier: NCT02105844.

摘要

背景

心房颤动是认知功能障碍发生的独立危险因素。经常喝咖啡已显示对健康个体有认知益处。经常喝咖啡是否能减少易患患者的认知衰退存在争议。我们调查了老年心房颤动患者中的这种关联。

方法与结果

使用结构化营养问卷评估每日咖啡摄入量，并通过详细的神经认知测试组评估认知功能，包括蒙特利尔认知评估、连线测验、语义流畅性测验和数字符号替换测验。认知综合得分结合了上述所有神经认知测试，提供了一个整体认知表现指标。测量高敏C反应蛋白（Hs-CRP）和白细胞介素-6（IL-6）以探讨与炎症的关联。结果使用线性混合效应模型估计，并对混杂因素进行详细调整。每天饮用咖啡少于1杯的消费者（参照组）的认知综合得分为-0.24（95%置信区间，-0.27至-0.16），而咖啡摄入量最高的组（每天>5杯）为-0.10（95%置信区间，-0.10至0.04；P=0.048）。参照组的蒙特利尔认知评估得分为24.58（95%置信区间，24.58 - 25.32）；摄入量最高的组达到25.25（95%置信区间，24.98 - 26.85；P=0.163）。随着咖啡摄入量增加，炎症标志物减少（高敏C反应蛋白，每天饮用5杯与少于1杯相比，系数为0.78 [95%置信区间，0.54 - 1.13]，P = 0.188，白细胞介素-6显著降低，系数为0.73 [95%置信区间，0.57 - 0.95]，P = 0.017）。