Thornton C S, Radu L, Boechler N, Clark J, Somayaji R
Cumming School of Medicine, University of Calgary, Calgary, Canada.
Department of Medicine, University of Calgary, Calgary, Canada.
Future Microbiol. 2025 Feb;20(3):259-264. doi: 10.1080/17460913.2024.2441010. Epub 2024 Dec 14.
Rhinosinusitis is a highly prevalent, inflammatory condition affecting the nose and paranasal sinuses, impacting an individual's quality of life with significant health care burden. Sinusitis is more frequent in females, and they typically present with more severe symptoms and worse quality of life scores. Males are more likely to present with nasal polyps and have higher objective scores on imaging studies. Differences in sinus microbiota by sex may play a role in understanding differences in clinical presentations between them, but additional research is required. An improved understanding of sex and gender-based differences in pathophysiology and clinical presentations will help to decrease inequities in accessing healthcare and optimizing long-term personalized patient outcomes.
鼻窦炎是一种高度常见的炎症性疾病，影响鼻子和鼻窦，给个人生活质量带来严重影响，并造成巨大的医疗负担。鼻窦炎在女性中更为常见，她们通常表现出更严重的症状和更低的生活质量评分。男性更易出现鼻息肉，在影像学检查中客观评分更高。性别导致的鼻窦微生物群差异可能在理解两者临床表现差异方面发挥作用，但还需要更多研究。更好地理解病理生理学和临床表现中基于性别的差异，将有助于减少医疗保健获取方面的不平等现象，并优化长期的个性化患者治疗效果。
