Talugula Snehitha, Chiu Richard, Nyenhuis Sharmilee M, Eldeirawi Kamal, Lee Victoria S
University of Illinois College of Medicine, 1853 W Polk St, Chicago, IL 60612, USA.
University of Illinois College of Medicine, 1853 W Polk St, Chicago, IL 60612, USA.
Am J Otolaryngol. 2024 Nov-Dec;45(6):104465. doi: 10.1016/j.amjoto.2024.104465. Epub 2024 Aug 3.
Chronic rhinosinusitis (CRS) is a widely prevalent condition, however its degree of severity according to sex requires further study. The literature shows that sex-based differences exist in the severity of asthma and allergic airway disease in the population. These findings point to a potential hormonal cause for this difference, but there is no study suggesting the role of sex in CRS with nasal polyps (CRSwNP). The purpose of this study was to examine the association of sex and CRSwNP severity in the United States.
This study was conducted on data gathered from 181 participants in the NAVIGATE I and NAVIGATE II randomized control trials within the OPTINOSE database. Participants were analyzed based on sex controlling for airway-related comorbidities, including history of asthma, race, and ethnicity. SNOT-22 scores were assessed as a quality-of-life outcome measure for CRS. The association between sex and SNOT-22 scores was determined using multiple linear regression.
There were 81 female and 100 male participants. SNOT-22 scores were significantly higher in females. The average reported SNOT-22 score was 53.8 ± 16.5 in females and 46.8 ± 18.8 in males. On adjusted regression, the association of sex and SNOT-22 scores approached but didn't reach significance (β: -4.97; 95 % CI: -10.68-0.73; p = 0.09).
On average, females had more severe manifestations of CRSwNP in comparison to males, with the adjusted association approaching statistical significance. Further studies, potentially looking at hormones as a cause of pathogenesis, are needed to better elucidate the role of sex in CRSwNP.
慢性鼻-鼻窦炎（CRS）是一种广泛流行的疾病，然而其严重程度在性别上的差异仍需进一步研究。文献表明，人群中哮喘和变应性气道疾病的严重程度存在基于性别的差异。这些发现指出了这种差异可能存在激素方面的原因，但尚无研究表明性别在伴鼻息肉的慢性鼻-鼻窦炎（CRSwNP）中所起的作用。本研究的目的是在美国探讨性别与CRSwNP严重程度之间的关联。
本研究的数据来自OPTINOSE数据库中NAVIGATE I和NAVIGATE II随机对照试验的181名参与者。根据性别对参与者进行分析，并对气道相关的合并症进行控制，包括哮喘病史、种族和民族。采用鼻窦鼻相关生活质量量表（SNOT-22）评分作为CRS生活质量的评估指标。使用多元线性回归确定性别与SNOT-22评分之间的关联。
共有81名女性和100名男性参与者。女性的SNOT-22评分显著更高。女性报告的SNOT-22平均评分为53.8±16.5，男性为46.8±18.8。在调整回归后，性别与SNOT-22评分之间的关联接近但未达到显著性（β：-4.97；95%CI：-10.68-0.73；p=0.09）。
平均而言，与男性相比，女性CRSwNP的表现更为严重，调整后的关联接近统计学显著性。需要进一步的研究，可能着眼于激素作为发病机制的一个原因，以更好地阐明性别在CRSwNP中的作用。
