Khani Nader, Bonyadi Mojtaba, Soleimani Roya Abedi, Raziabad Reza Hazrati, Ahmadi Mehdi, Homayouni-Rad Aziz
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Food Science and Technology, Faculty of Nutrition & Food Sciences, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Probiotics Antimicrob Proteins. 2025 Jun;17(3):1513-1522. doi: 10.1007/s12602-024-10416-y. Epub 2024 Dec 14.
Celiac disease (CD) can be considered an autoimmune problem, a disease caused by gluten sensitivity in the body. Gluten is found in foods such as barley, wheat, and rye. This ailment manifests in individuals with hereditary susceptibility and under the sway of environmental stimulants, counting, in addition to gluten and intestinal microbiota dysbiosis. Currently, the only recommended treatment for this condition is to follow a gluten-free diet for life. In this review, we scrutinized the studies of recent years that focused on the use of postbiotics in vitro and in vivo in CD. The investigation of postbiotics in CD could be intriguing to observe their diverse effects on several pathways. This study highlights the definitions, characteristics, and safety issues of postbiotics and their possible biological role in the prevention and treatment of CD, as well as their application in the food and drug industry.
乳糜泻（CD）可被视为一种自身免疫性问题，是一种由体内麸质敏感性引起的疾病。麸质存在于大麦、小麦和黑麦等食物中。这种疾病在具有遗传易感性且受环境刺激因素影响的个体中表现出来，除了麸质和肠道微生物群失调外，还包括其他因素。目前，针对这种疾病唯一推荐的治疗方法是终身遵循无麸质饮食。在本综述中，我们仔细研究了近年来聚焦于后生元在乳糜泻体外和体内应用的研究。对乳糜泻中后生元的研究可能会很有趣，以观察它们在多种途径上的不同作用。本研究强调了后生元的定义、特性和安全性问题，以及它们在乳糜泻预防和治疗中的可能生物学作用，以及它们在食品和制药行业中的应用。
