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Sleep homeostatic and circadian clock changes can be obtained by manipulating one single kinase, but do the two processes meet each other there?通过操纵单一激酶即可实现睡眠稳态和生物钟的变化，但这两个过程在那里会相互交汇吗？
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2
Sleep homeostasis and the circadian clock: Do the circadian pacemaker and the sleep homeostat influence each other's functioning?睡眠稳态与生物钟：生物钟起搏器和睡眠稳态机制是否相互影响对方的功能？
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Circadian clock genes and sleep homeostasis.昼夜节律时钟基因与睡眠稳态。
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本文引用的文献

1
Partial activation of salt-inducible kinase 3 delays the onset of wakefulness and alleviates hypersomnia due to the lack of protein kinase A-phosphorylation site.盐诱导激酶3的部分激活可延迟清醒的开始，并减轻因缺乏蛋白激酶A磷酸化位点而导致的失眠。
Sleep. 2025 Feb 10;48(2). doi: 10.1093/sleep/zsae279.
2
Sleep and circadian rhythmicity as entangled processes serving homeostasis.睡眠和昼夜节律作为维持内稳态的纠缠过程。
Nat Rev Neurosci. 2024 Jan;25(1):43-59. doi: 10.1038/s41583-023-00764-z. Epub 2023 Dec 1.
3
SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.在视交叉上核中 SIK3-HDAC4 调控小鼠暗期起始时觉醒的时间和昼夜节律周期。
Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2218209120. doi: 10.1073/pnas.2218209120. Epub 2023 Mar 6.
4
Kinase signalling in excitatory neurons regulates sleep quantity and depth.兴奋性神经元中的激酶信号传导调节睡眠量和深度。
Nature. 2022 Dec;612(7940):512-518. doi: 10.1038/s41586-022-05450-1. Epub 2022 Dec 7.
5
Adenosine, caffeine, and sleep-wake regulation: state of the science and perspectives.腺苷、咖啡因与睡眠-觉醒调节：科学现状与展望。
J Sleep Res. 2022 Aug;31(4):e13597. doi: 10.1111/jsr.13597. Epub 2022 May 16.
6
A role for the cortex in sleep-wake regulation.大脑皮层在睡眠-觉醒调节中的作用。
Nat Neurosci. 2021 Sep;24(9):1210-1215. doi: 10.1038/s41593-021-00894-6. Epub 2021 Aug 2.
7
Sleep homeostasis and the circadian clock: Do the circadian pacemaker and the sleep homeostat influence each other's functioning?睡眠稳态与生物钟：生物钟起搏器和睡眠稳态机制是否相互影响对方的功能？
Neurobiol Sleep Circadian Rhythms. 2018 Mar 1;5:68-77. doi: 10.1016/j.nbscr.2018.02.003. eCollection 2018 Jun.
8
A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice.SIK3 的一个单一磷酸化位点调节小鼠的每日睡眠时间和睡眠需求。
Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10458-10463. doi: 10.1073/pnas.1810823115. Epub 2018 Sep 25.
9
Forward-genetics analysis of sleep in randomly mutagenized mice.对随机诱变小鼠睡眠的正向遗传学分析。
Nature. 2016 Nov 17;539(7629):378-383. doi: 10.1038/nature20142. Epub 2016 Nov 2.
10
The two-process model of sleep regulation: a reappraisal.睡眠调节的双过程模型：重新评估
J Sleep Res. 2016 Apr;25(2):131-43. doi: 10.1111/jsr.12371. Epub 2016 Jan 14.

Sleep homeostatic and circadian clock changes can be obtained by manipulating one single kinase, but do the two processes meet each other there?

作者信息

Deboer Tom

机构信息

Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

出版信息

Sleep. 2025 Feb 10;48(2). doi: 10.1093/sleep/zsae291.

DOI:10.1093/sleep/zsae291
PMID:39673772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11807888/
Abstract
摘要