Liao Yonghong, Kong Yueyao, Chen Hongyu, Xia Jing, Zhao Jianjun, Zhou Yang
College of Veterinary Medicine, Southwest University, 402460 Chongqing, China; National Center of Technology Innovation for Pigs, 402460, Rongchang, Chongqing, China.
College of Veterinary Medicine, Southwest University, 402460 Chongqing, China.
Int Immunopharmacol. 2025 Jan 27;146:113821. doi: 10.1016/j.intimp.2024.113821. Epub 2024 Dec 13.
The NLRP3 inflammasome plays a pivotal role in the innate immune response. Its activation involves a two-step mechanism that consists of priming and activation. The priming of the NLRP3 inflammasome is a vital initial phase necessary for its activation and subsequent involvement in the immune response, though its understanding varies across studies. Recent research has identified key proteins that influence the priming process, revealing a sophisticated regulatory network. This review provides a comprehensive review of the priming phase of NLRP3 inflammasome activation, with a particular focus on the underlying molecular mechanisms, including transcriptional regulation, orchestration of the phosphorylation status, deubiquitination and the relationships with the inflammation-associated diseases. Understanding the intricacies of NLRP3 inflammasome priming not only elucidates fundamental aspects of immune regulation, but also provides potential avenues for therapeutic intervention in inflammatory diseases.
NLRP3炎性小体在固有免疫反应中起关键作用。其激活涉及一个由启动和激活组成的两步机制。NLRP3炎性小体的启动是其激活及随后参与免疫反应所必需的重要初始阶段，不过不同研究对其的理解有所不同。最近的研究已鉴定出影响启动过程的关键蛋白，揭示了一个复杂的调控网络。本综述全面回顾了NLRP3炎性小体激活的启动阶段，特别关注潜在的分子机制，包括转录调控、磷酸化状态的调控、去泛素化以及与炎症相关疾病的关系。了解NLRP3炎性小体启动的复杂性不仅能阐明免疫调节的基本方面，还为炎症性疾病的治疗干预提供了潜在途径。
