Rus Alma, Coca-Guzmán Bárbara, Molina Francisco, Correa-Rodríguez María, Martínez-Martos José Manuel, Ramírez-Expósito María Jesús, Aguilar-Ferrándiz María Encarnación
Department of Cell Biology, University of Granada, Avenida de la Fuentenueva, s/n, 18071 Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, 18012 Granada, Spain.
Department of Cell Biology, University of Granada, Avenida de la Fuentenueva, s/n, 18071 Granada, Spain; Department of Physical Therapy, Faculty of Health Sciences, University of Granada, Avenida de la Ilustración, 60, 18016 Granada, Spain.
Maturitas. 2025 Feb;193:108171. doi: 10.1016/j.maturitas.2024.108171. Epub 2024 Dec 10.
Fibromyalgia is a complex syndrome that appears more frequently during menopause. No previous studies have investigated the effect of menopause on amino acids in women with fibromyalgia. Therefore, we have examined serum amino acid concentrations in premenopausal and postmenopausal women with fibromyalgia and healthy women.
A case-control study was carried out in 28 premenopausal and 46 postmenopausal healthy women and in 16 premenopausal and 52 postmenopausal women with fibromyalgia. This study adheres to STROBE guidelines.
Amino acid content was assayed using high-performance liquid chromatography.
Significant differences were found in concentrations of several amino acids (aspartic acid, glutamic acid, histidine, glycine, alanine, leucine, and taurine) between healthy premenopausal women and premenopausal women with fibromyalgia and between healthy postmenopausal women and postmenopausal women with fibromyalgia. Concentrations of other amino acids (aminoadipic acid, asparagine, threonine, arginine, 5-methyl-histidine, valine, methionine, isoleucine, phenylalanine, ornithine, branched-chain amino acids, large neutral amino acids, essential amino acids, non-essential amino acids, basic amino acids, and arginine/ornithine ratio) were found to differ between healthy postmenopausal women and postmenopausal women with fibromyalgia, but not between healthy premenopausal women and premenopausal women with fibromyalgia. No significant differences were found in serum amino acid concentrations between premenopausal and postmenopausal healthy women or between premenopausal and postmenopausal women with fibromyalgia.
Our results show, for the first time, that the association between menopause and fibromyalgia may increase the risk of metabolic disorders by disrupting amino acid homeostasis to a greater extent than menopause or fibromyalgia alone.
纤维肌痛是一种复杂的综合征，在绝经期间更频繁出现。以前没有研究调查过绝经对纤维肌痛女性氨基酸的影响。因此，我们检测了绝经前和绝经后纤维肌痛女性以及健康女性的血清氨基酸浓度。
对28名绝经前和46名绝经后健康女性以及16名绝经前和52名绝经后纤维肌痛女性进行了病例对照研究。本研究遵循STROBE指南。
采用高效液相色谱法测定氨基酸含量。
在健康绝经前女性与绝经前纤维肌痛女性之间以及健康绝经后女性与绝经后纤维肌痛女性之间，几种氨基酸（天冬氨酸、谷氨酸、组氨酸、甘氨酸、丙氨酸、亮氨酸和牛磺酸）的浓度存在显著差异。发现其他氨基酸（氨基己二酸、天冬酰胺、苏氨酸、精氨酸、5-甲基组氨酸、缬氨酸、蛋氨酸、异亮氨酸、苯丙氨酸、鸟氨酸、支链氨基酸、大中性氨基酸、必需氨基酸、非必需氨基酸、碱性氨基酸以及精氨酸/鸟氨酸比值）在健康绝经后女性与绝经后纤维肌痛女性之间存在差异，但在健康绝经前女性与绝经前纤维肌痛女性之间无差异。绝经前和绝经后健康女性之间或绝经前和绝经后纤维肌痛女性之间的血清氨基酸浓度无显著差异。
我们的结果首次表明，绝经与纤维肌痛之间的关联可能比单独的绝经或纤维肌痛更严重地破坏氨基酸稳态，从而增加代谢紊乱的风险。
