Ruggiero Valeria, Mura Massimiliano, Cacace Enrico, Era Benedetta, Peri Marcella, Sanna Giuseppina, Fais Antonella
a Dipartimento di Scienze Mediche e Sanità Pubblica , Università di Cagliari , Monserrato , Cagliari , Italy.
b Ospedale Pediatrico "A. Cao", Azienda Ospedaliera Brotzu , Cagliari , Italy.
Scand J Clin Lab Invest. 2017 Apr;77(2):93-97. doi: 10.1080/00365513.2016.1269362. Epub 2017 Jan 12.
The objectives of our study were to evaluate free amino acid (FAA) concentrations in the serum of patients affected by fibromyalgia syndrome (FMS) and to determine the relationships between FAA levels and FMS clinical parameters. Thus, serum amino acid concentrations were quantified (HPLC analysis) in 23 females with fibromyalgia (according to the American College of Rheumatology classification criteria) and 20 healthy females. The results showed significantly higher serum concentrations of aspartate, cysteine, glutamate, glycine, isoleucine, leucine, methionine, ornithine, phenylalanine, sarcosine, serine, taurine, tyrosine and valine in FMS patients vs. healthy controls. Patients with higher Fibromyalgia Impact Questionnaire (FIQ) scores showed increased levels of alanine, glutamine, isoleucine, leucine, phenylalanine, proline and valine. In conclusion, our results indicate an imbalance in some FAAs in FMS patients. Increased Glu is particularly interesting, as it could explain the deficit in monoaminergic transmission involved in pain.
我们研究的目的是评估纤维肌痛综合征（FMS）患者血清中的游离氨基酸（FAA）浓度，并确定FAA水平与FMS临床参数之间的关系。因此，我们对23名符合美国风湿病学会分类标准的纤维肌痛女性患者和20名健康女性的血清氨基酸浓度进行了定量分析（采用高效液相色谱法）。结果显示，与健康对照组相比，FMS患者血清中天冬氨酸、半胱氨酸、谷氨酸、甘氨酸、异亮氨酸、亮氨酸、蛋氨酸、鸟氨酸、苯丙氨酸、肌氨酸、丝氨酸、牛磺酸、酪氨酸和缬氨酸的浓度显著更高。纤维肌痛影响问卷（FIQ）得分较高的患者，其血清中丙氨酸、谷氨酰胺、异亮氨酸、亮氨酸、苯丙氨酸、脯氨酸和缬氨酸的水平升高。总之，我们的结果表明FMS患者体内某些FAA存在失衡。谷氨酸水平升高尤其值得关注，因为它可能解释了疼痛相关单胺能传递的缺陷。
