Muniz Emiro G, Sano-Martins Ida S, Saraiva Maria das Graças G, Magno Evela S, Oliveira Sâmella S
Department of Epidemiology and Public Health, Dr Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, 69040-000, Brazil.
Pathophysiology Laboratory, Butantan Institute, São Paulo, 05503-900, Brazil.
Toxicon. 2025 Jan;254:108211. doi: 10.1016/j.toxicon.2024.108211. Epub 2024 Dec 17.
We evaluated the efficacy of freeze-dried Bothrops-Lachesis-Crotalus antivenom and liquid Crotalus antivenoms to neutralize Crotalus durissus ruruima (Cdr) venom (Roraima, Brazil) comparing with C. d. terrificus (Cdt) venom. Lethal and phospholipase A activities were similar between both spp. Crotamine was negative and individual Cdr venoms induced hemorrhage in mice. It was lower coagulant than Cdt venom. Only Bothrops-Lachesis-Crotalus antivenom neutralized all biological activities evaluated, suggesting that it could be used in snakebites in this region.
我们评估了冻干的矛头蝮-睫角蝰-响尾蛇抗蛇毒血清和液体响尾蛇抗蛇毒血清中和杜氏响尾蛇鲁里马亚种（Cdr，巴西罗赖马州）毒液与杜氏响尾蛇恐怖亚种（Cdt）毒液的效果。两种蛇毒的致死活性和磷脂酶A活性相似。响尾蛇毒素呈阴性，且单个Cdr毒液可致使小鼠出血。其凝血性低于Cdt毒液。只有矛头蝮-睫角蝰-响尾蛇抗蛇毒血清中和了所有评估的生物活性，这表明它可用于该地区的蛇咬伤治疗。
