Wang Ya-Nan, Liu Shiyue
Department of Implantology & Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong 250012, China; Suzhou Research Institute, Shandong University, Suzhou, Jiangsu 215123, China.
Department of Implantology & Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong 250012, China.
Int J Biol Macromol. 2025 Feb;288:138760. doi: 10.1016/j.ijbiomac.2024.138760. Epub 2024 Dec 12.
Lipid peroxidation presents the oxidative degradation of polyunsaturated fatty acids lincited by reactive species. Excessive accumulation of lipid peroxidation byproducts, including 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA), causes protein dysfunction and various illnesses. Aldehyde dehydrogenases (ALDHs) catalyze the metabolism of both endogenous and exogenous aldehydes. These enzymes participate in detoxification and intermediary metabolism. Contemporary research has affirmed the involvement of both enzymatic and non-enzymatic pathways of ALDHs in modulating the evolution of diseases associated with lipid peroxidation. This review provides an overview of the biological functions and clinical implications concerning the enzymatic and non-enzymatic pathways of ALDHs in diseases related to lipid peroxidation, such as, non-alcoholic fatty liver disease (NAFLD), atherosclerosis, and type 2 diabetes (T2DM). Furthermore, the activators or inhibitors of ALDHs represent a promising therapeutic strategy for lipid peroxidation-related diseases.
脂质过氧化是指由活性物质引发的多不饱和脂肪酸的氧化降解。脂质过氧化副产物（包括4-羟基-2-壬烯醛（4-HNE）和丙二醛（MDA））的过度积累会导致蛋白质功能障碍和各种疾病。醛脱氢酶（ALDHs）催化内源性和外源性醛的代谢。这些酶参与解毒和中间代谢。当代研究证实，ALDHs的酶促和非酶促途径均参与调节与脂质过氧化相关疾病的发展。本文综述了ALDHs的酶促和非酶促途径在与脂质过氧化相关疾病（如非酒精性脂肪性肝病（NAFLD）、动脉粥样硬化和2型糖尿病（T2DM））中的生物学功能和临床意义。此外，ALDHs的激活剂或抑制剂代表了一种有前景的脂质过氧化相关疾病治疗策略。
