Gholami Farhad, Mesrabadi Javad, Iranpour Mohadeseh, Donyaei Adel
Department of Physical Education and Sport Sciences, Faculty of Physical Education, Shahrood University of Technology, Shahrood, Semnan, Iran.
Department of Educational Psychology, Psychology and Educational Science Faculty, University of Azarbai-jan Shahid Madani, Tabriz, Iran.
Exp Gerontol. 2025 Jan;199:112658. doi: 10.1016/j.exger.2024.112658. Epub 2024 Dec 16.
This systematic review with meta-analysis investigated the effects of exercise training on brain-derived neurotrophic factor (BDNF) in older adults. Electronic databases of PubMed, Web of Science and Scopus were searched for studies investigating the effect of exercise training ≥4 weeks on resting BDNF levels in older adults. A standardized mean difference (SMD) was generated through random effects model. Thirty-five randomized-controlled trials met the inclusion criteria. Exercise training significantly increased resting BDNF levels [SMD = 0.56 (95 % CI 0.28 to 0.85)] both in plasma (SMD = 0.63) and serum (SMD = 0.54). Regarding exercise modality, aerobic (SMD = 0.48), resistance (SMD = 0.76) and combined exercise training (SMD = 0.55) increased BDNF levels. Exercise training with the duration of 12 weeks (SMD =0.65), moderate-to-vigorous (SMD = 0.83) and vigorous intensity (SMD = 0.71), and 3-4 sessions per week frequency (SMD = 0.78) yielded the largest effects on BDNF elevation. Since BDNF represents a fundamental contribution in neuronal processes and is linked to brain health, exercise training may help delay aging-related neuro-degenerative processes. REGISTRATION NUMBER: CRD42024499195.
这项包含荟萃分析的系统评价研究了运动训练对老年人脑源性神经营养因子（BDNF）的影响。检索了PubMed、科学网和Scopus等电子数据库，以查找研究运动训练≥4周对老年人静息BDNF水平影响的研究。通过随机效应模型生成标准化平均差（SMD）。35项随机对照试验符合纳入标准。运动训练显著提高了血浆（SMD = 0.63）和血清（SMD = 0.54）中的静息BDNF水平[SMD = 0.56（95%CI 0.28至0.85）]。关于运动方式，有氧运动（SMD = 0.48）、抗阻运动（SMD = 0.76）和联合运动训练（SMD = 0.55）均可提高BDNF水平。持续12周（SMD = 0.65）、中等至剧烈强度（SMD = 0.83）和剧烈强度（SMD = 0.71）以及每周3 - 4次训练频率（SMD = 0.78）的运动训练对BDNF升高的影响最大。由于BDNF在神经元过程中起着重要作用且与大脑健康相关，运动训练可能有助于延缓与衰老相关的神经退行性过程。注册号：CRD42024499195。
